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The total variation regularizer is diffusely emerged in statistics, image and signal processing to obtain piecewise constant estimator. The ℓ total variation (L0TV) regularized signal denoising model is a nonconvex and discontinuous optimization problem, and it is very difficult to find its global optimal solution. In this paper, we present the global optimality analysis of L0TV signal denoising model, and design an efficient algorithm to pursuit its solution. Firstly, we equivalently rewrite the L0TV denoising model as a partial regularized (PL0R) minimization problem by aid of the structured difference operator. Subsequently, we define a P-stationary point of PL0R, and show that it is a global optimal solution. These theoretical results allow us to find the global optimal solution of the L0TV model. Therefore, an efficient Newton-type algorithm is proposed for the PL0R problem. The algorithm has a considerably low computational complexity in each iteration. Finally, experimental results demonstrate the excellent performance of our approach in comparison with several state-of-the-art methods.
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http://dx.doi.org/10.3934/mbe.2023299 | DOI Listing |
Biomed Phys Eng Express
September 2025
Siemens Healthineers AG, 810 Innovation Dr, Knoxville, Tennessee, 37932-2562, UNITED STATES.
Achieving high-quality PET imaging while minimizing scan time and patient radiation dose presents significant challenges, particularly in the absence of CT-based attenuation maps. Joint reconstruction algorithms, such as MLAA and MLACF, partially address these challenges but often result in noisy and less reliable images. Denoising these images is critical for enhancing diagnostic accuracy.
View Article and Find Full Text PDFPhys Med Biol
September 2025
BioMaps, Université Paris-Saclay, CNRS, Inserm, SHFJ, CEA, 4 Place du général Leclerc, Orsay, Île-de-France, 91401, FRANCE.
Deep learning has shown great promise for improving medical image reconstruction, including PET. However, concerns remain about the stability and robustness of these methods, especially when trained on limited data. This work aims to explore the use of the Plug-and-Play (PnP) framework in PET reconstruction to address these concerns.
View Article and Find Full Text PDFPLoS One
September 2025
The Institute of Port Information Digitalization, China Liaoning Port Group Co. Ltd., Dalian, Liaoning, China.
Background: Underwater environments face challenges with image degradation due to light absorption and scattering, resulting in blurring, reduced contrast, and color distortion. This significantly impacts underwater exploration and environmental monitoring, necessitating advanced algorithms for effective enhancement.
Objectives: The study aims to develop an innovative underwater image enhancement algorithm that integrates physical models with deep learning to improve visual quality and surpass existing methods in performance metrics.
Nucleic Acids Res
September 2025
School of Software, Shandong University, Jinan 250101, Shandong, China.
Spatial transcriptomics (ST) reveals gene expression distributions within tissues. Yet, predicting spatial gene expression from histological images still faces the challenges of limited ST data that lack prior knowledge, and insufficient capturing of inter-slice heterogeneity and intra-slice complexity. To tackle these challenges, we introduce FmH2ST, a foundation model-based method for spatial gene expression prediction.
View Article and Find Full Text PDFAnal Chem
September 2025
State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong SAR 999077, China.
Mass spectrometry imaging (MSI) is a label-free technique that enables the visualization of the spatial distribution of thousands of ions within biosamples. Data denoising is the computational strategy aimed at enhancing the MSI data quality, providing an effective alternative to experimental methods. However, due to the complex noise pattern inherent in MSI data and the difficulty in obtaining ground truth from noise-free data, achieving reliable denoised images remains challenging.
View Article and Find Full Text PDF