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The effective and convenient detection of single photons via advanced detectors with a large active area is becoming significant for quantum and classical applications. This work demonstrates the fabrication of a superconducting microstrip single-photon detector (SMSPD) with a millimeter-scale active area via the use of ultraviolet (UV) photolithography. The performances of NbN SMSPDs with different active areas and strip widths are characterized. SMSPDs fabricated by UV photolithography and electron beam lithography with small active areas are also compared from the aspects of the switching current density and line edge roughness. Furthermore, an SMSPD with an active area of 1 mm × 1 mm is obtained via UV photolithography, and during operation at 0.85 K, it exhibits near-saturated internal detection efficiency at wavelengths up to 800 nm. At a wavelength of 1550 nm, the detector exhibits a system detection efficiency of ∼5% (7%) and a timing jitter of 102 (144) ps, when illuminated with a light spot of ∼18 (600) µm in diameter, respectively.
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http://dx.doi.org/10.1364/OE.487024 | DOI Listing |
JMIR Res Protoc
September 2025
Department of Development & Environmental Studies, Palacký University Olomouc, Olomouc, Czech Republic.
Background: Children in low- and middle-income countries face obstacles to optimal language and cognitive development due to a variety of factors related to adverse socioeconomic conditions. One of these factors is compromised caregiver-child interactions and associated pressures on parenting. Early development interventions, such as dialogic book-sharing (DBS), address this variable, with evidence from both high-income countries and urban areas of low- and middle-income countries showing that such interventions enhance caregiver-child interaction and the associated benefits for child cognitive and socioemotional development.
View Article and Find Full Text PDFMacromol Rapid Commun
September 2025
Karlsruhe Institute of Technology, Karlsruhe, Germany.
Within this special issue we would like to celebrate 200 years of the Karlsruhe Institute of Technology (KIT) and the former Technical University Karlsruhe/Germany. The Technical University Karlsruhe served, according to the first president of MIT, William Barton Rogers, as the role model for the planned MIT in Boston/USA after he visited Karlsruhe. All authors of this special issue of Macromolecular Rapid Communications have been or are still active in Karlsruhe.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
September 2025
IQRAA Centre for Research and Development, IQRAA International Hospital and Research Centre, Kozhikode, Kerala, India.
Terminalia arjuna, an important medicinal plant in traditional Indian systems, has been extensively studied for its cardioprotective bark. However, limited attention has been given to its fruit, which contains several biologically active phytochemicals with potential antioxidant, anti-inflammatory, and immunomodulatory properties. This study aimed to isolate and partially purify phytoactive compounds from the fruit of T.
View Article and Find Full Text PDFAppl Biochem Biotechnol
September 2025
Programa de Engenharia Química/COPPE, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21941-972, Rio de Janeiro, Brazil.
Polymer particles, including synthetic polymers such as poly(methyl methacrylate) (PMMA) and poly(styrene-co-divinylbenzene) (P(S-co-DVB)) beads, have been widely used as enzymatic supports and drug carriers. In this sense, it is important to understand the stabilization or degradation of such polymer matrices under specific chemical and enzymatic media. For this reason, the present work aims to evaluate the current status and prospects of treatments of PMMA and P(S-co-DVB) particles intended for biotechnological and biomedical applications under basic, acidic, and enzymatic environments.
View Article and Find Full Text PDFArch Microbiol
September 2025
Medical and Biological Computing Laboratory, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, 632014, India.
Salmonella enterica serovar Typhi, the etiological agent of Typhoid fever, remains a critical public health concern associated with high morbidity in many developing countries. The widespread emergence of multidrug-resistant (MDR) Salmonella Typhi strains against the fluoroquinolone group of antibiotics, particularly ciprofloxacin, poses a significant global therapeutic challenge with underlying resistance due to mutations in quinolone-resistance determining region (QRDR) of gyrA gene, encoding DNA gyrase subunit A (GyrA). In pursuit of alternative therapeutic candidates, the present study was designed to evaluate ciprofloxacin analogues against prevalent GyrA mutations (S83F, D87G, and D87N) to overcome fluoroquinolone resistance through machine learning (ML)-based approach.
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