Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) are important indicators of cardiovascular, muscle and liver lesions, and can be used as prognostic indicators for infectious diseases, such as coronavirus disease 2019 (COVID-19). The present systematic review and meta-analysis assessed the prognostic value of LDH and AST levels for COVID-19 severity. Ovid-Medline, PubMed, Embase and The Cochrane Library were used to search for articles, according to the inclusion and exclusion criteria, until July 2022. The meta-analysis was performed using Revman5.3 and Stata15.1. Standardized mean difference (SMD) and 95% confidence intervals (CIs) of LDH and AST concentrations were analyzed using a random-effects model. Heterogeneity was investigated using meta-regression and subgroup methods. A total of 4,342 patients with COVID-19 in 23 articles were included in the present study. LDH (SMD=1.21; 95% CI: 0.98, 1.44) and AST (SMD=0.68; 95% CI: 0.54, 0.81) were significantly higher in patients with severe COVID-19 compared with in those with non-severe COVID-19. Serum LDH and AST levels in critically ill patients with COVID-19 were increased, suggesting a correlation between the levels of LDH and AST and the severity of COVID-19. These findings may help to develop a risk-stratified approach to the care of patients with this disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133797 | PMC |
| http://dx.doi.org/10.3892/etm.2023.11920 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sodium Orthovanadate (SOV) mitigates alcohol & alcohol plus high-fat diet (HFD)-induced hepatotoxicity in rats.
Cell Mol Biol (Noisy-le-grand)
September 2025
Associate Professor, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh-Punjab 147301, India.
Alcoholic fatty liver disease (AFLD) is a leading cause of chronic liver disease worldwide, contributing to significant morbidity and mortality. Despite its growing prevalence, no FDA-approved pharmacological treatments exist, leaving lifestyle modifications as the primary intervention. AFLD pathogenesis involves a complex interplay of lipid accumulation, oxidative stress, insulin resistance, and inflammation, highlighting the need for innovative therapeutic approaches.
View Article and Find Full Text PDFHepatoprotective potential of Diospyros melanoxylon (Roxb.) leaf extract by inhibition of IL-6, COX-2, and 5-LOX expression in paracetamol intoxicated rats.
J Ethnopharmacol
August 2025
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, 751003, Odisha, India. Electronic address:
Ethnopharmacological Relevance: Diospyros melanoxylon, Roxb., (Ebenaceae), native to South and Southeast Asia, has been traditionally used to treat liver disorders, jaundice, tuberculosis, and chronic wounds and inflammatory conditions.
Aim Of The Study: To evaluate the hepatoprotective effect of D.
FEATURES OF THE EFFECT OF SCORPION VENOM ON THE IMMUNE DEFENSE SYSTEM OF THE MAMMALIAN LIVER (REVIEW).
Georgian Med News
June 2025
3Clinical Medicine Department, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv, Ukraine.
Introduction: Toxic liver damage due to exposure to poisons, including those of animal origin, is often associated with lymphocytic infiltration, and the nature and degree of inflammation determine the rate of progression and severity of damage. The mechanisms by which toxic compounds activate immune-mediated pathways of liver damage are still being actively studied, however, liver infiltration by effector lymphocytes is a common phenomenon, leading to the destruction of hepatocytes and cholangiocytes and a persistent shift in the structural and functional characteristics of the organ Aim of study: To determine the features of the effect of scorpion venom on the immune defense system of the mammalian liver.
Materials And Methods: A thorough literature analysis was conducted on the basis of PubMed, Google Scholar, Web of Science, and Scopus databases.
The Impact of Endurance Exercise on Routine Laboratory Parameters in Young Trained Individuals.
J Clin Med
August 2025
Department of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp. Al., 70-111 Szczecin, Poland.
: Endurance effort aims to improve aerobic capacity. During physical exertion, fluid shifts from intravascular to interstitial spaces, affecting potential conclusions from laboratory test results. The study aimed to assess the effects of endurance exercise on clinical interpretations of routine laboratory hematological and biochemical diagnostic tests.
View Article and Find Full Text PDFPrognostic Impact of Vaccination, Comorbidity, and Inflammatory Biomarkers on Clinical Outcome in Hospitalized Patients with COVID-19.
Biomedicines
August 2025
Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia.
: The coronavirus disease 2019 (COVID-19) has more severe symptoms and increased mortality among men than women. To address the prognostic impact of vaccination, comorbidities, and inflammatory biomarkers on classified clinical outcomes in hospitalized COVID-19 patients, we compared common and sex differences. : Besides laboratory and clinical parameters at hospital admission, we performed a common and sex-based comparative analysis for the clinical outcomes, RT-qPCR analyses, and measured severe acute respiratory syndrome coronavirus (SARS-CoV-2)-specific IgM and IgG antibody levels of 702 COVID-19 patients in a single centre from June 2020 to April 2022.
View Article and Find Full Text PDF