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http://dx.doi.org/10.1093/ced/llad164 | DOI Listing |
Nat Commun
March 2025
Caris Life Sciences, 4610 S 44th Pl, Phoenix, AZ, 85040, USA.
The US Food and Drug Administration approves tissue-agnostic therapies to target tumor biomarkers regardless of tumor type. In light of the growing number of such approvals in recent years, a better understanding of their relative clinical benefit across cancer types is required. To address this need, we analyzed tissue-agnostic indications (TMB-High, MSI-High/MMRd, BRAF mutations, and NTRK and RET fusions) in a database of 295,316 molecularly-profiled tumor samples with associated clinical outcomes data.
View Article and Find Full Text PDFClin Exp Dermatol
August 2023
Departments of Dermatology.