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Three Colombian patients with chronic HTLV-1 infection and severe intermediate and/or posterior uveitis are described. In one case, retinal ablation was necessary due to extensive peripheral degeneration, while the other two were successfully managed with local anti-inflammatory therapy. Gradual resolution of ocular findings was observed in all three patients on follow-up. Uveitis is a rarely recognized late complication of this infection, which represents a diagnostic and therapeutic challenge for clinicians in endemic countries. The real extension of HTLV-1 prevalence in Colombia and the frequency of its ophthalmologic complications remain to be determined.
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http://dx.doi.org/10.1177/20499361231165864 | DOI Listing |
Curr Opin Virol
September 2025
Department of Hematology, Rheumatology and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:
Human T-cell leukemia virus type I (HTLV-1) was the first human pathogenic retrovirus to be discovered. HTLV-1 induces a T-cell malignancy, adult T-cell leukemia-lymphoma (ATL), and inflammatory diseases, such as HTLV-1-associated myelopathy (HAM), HTLV-1 uveitis (HU), and HTLV-1-associated pulmonary disease (HAPD). Importantly, HTLV-1 maintains persistent infection by regulating viral gene expression and disrupting host signaling pathways - activities that are closely linked to its pathogenicity.
View Article and Find Full Text PDFOcul Immunol Inflamm
July 2025
Miyata Eye Hospital, Miyakonojo, Japan.
Purpose: To investigate the epidemiology, clinical features, laterality, and long-term visual prognosis of uveitis.
Methods: This is a retrospective observational study.
Results: We included 1362 patients diagnosed with uveitis at Miyata Eye Hospital, Japan, from 2015 to 2020.
J Fr Ophtalmol
December 2024
Service d'ophtalmologie, faculté de médecine, CHU Fattouma Bourguiba, université de Monastir, Monastir, Tunisie. Electronic address:
J Med Virol
October 2024
Department of Ophthalmology & Visual Science, Graduate school of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Human T-cell Lymphotropic Virus Type 1 (HTLV-1) is traditionally linked to severe conditions such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy, and HTLV-1 uveitis, with vertical transmission, particularly mother to child thorough breastfeeding, considered the primary route. Despite efforts to reduce vertical transmission through antenatal screening in Japan, horizontal transmission has contributed to the rising prevalence of HTLV-1 in metropolitan areas. This case reports the youngest documented instance of HTLV-1 uveitis resulting from horizontal transmission through sexual contact in an 18-year-old woman.
View Article and Find Full Text PDFVaccine X
August 2024
Department of Microbiology and Virology, Alborz University of Medical Science, Alborz, Iran.
Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that is distinguished for its correlation to myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). As well, HTLV-1 has been documented to have links with other inflammatory diseases, such as uveitis and dermatitis. According to the World Health Organization (WHO), the global distribution of HTLV-1 infection is estimated to extend between 5 and 10 million individuals.
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