Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Sleep disorders, including insomnia, are common during aging, and these conditions have been associated with cognitive decline in older adults. Moreover, during the aging process, neurotransmitters, neurohormones, and neurotrophins decrease significantly, leading to the impairment of cognitive functions. In this sense, BDNF, the most abundant neurotrophic factor in the human brain, has been suggested as a potential target for the prevention and improvement of cognitive decline during aging; however, the current evidence demonstrates that the exogenous administration of BDNF does not improve cognitive function. Hence, in the present study, we quantified pro-BDNF (inactive) and BDNF (active) concentrations in serum samples derived from older individuals with insomnia and/or cognitive decline. We used linear regression to analyze whether clinical or sociodemographic variables impacted the levels of BNDF concentration. We observed that insomnia, rather than cognitive decline, is significantly associated with BDNF concentration, and these effects are independent of other variables. To our knowledge, this is the first study that points to the impact of insomnia on improving the levels of BDNF during aging and suggests that opportune treatment of insomnia may be more beneficial to prevent cognitive decline during aging.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139029 | PMC |
| http://dx.doi.org/10.3390/ijms24087387 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mobility impairment and fall concern predict wayfinding ability in persons with multiple sclerosis.
Mult Scler Relat Disord
September 2025
Department of Psychology, Wayne State University, Detroit, MI, 48202, USA; Institute of Gerontology, Wayne State University, Detroit, MI, 48202, USA; Translational Neuroscience Program, Wayne State University, Detroit, MI, 48201, USA. Electronic address:
The ability to navigate through one's environment is crucial for maintaining independence in daily life and depends on complex cognitive and motor functions that are vulnerable to decline in persons with Multiple Sclerosis (MS). While previous research suggests a role for mobility in the physical act of navigation, it remains unclear to what extent mobility impairment and perceptions of mobility constraints may modify wayfinding and the recall of environment details in support of successful navigation. Therefore, this study examined the relations among clinical mobility function, concern about falling, and recall of environment details in a clinical sample of MS.
View Article and Find Full Text PDFChanges in DTI-ALPS index and its associations with neuronal damage in Lewy body disease.
Parkinsonism Relat Disord
September 2025
Translational and Clinical Research Institute, Newcastle University, UK.
Introduction: Dysfunction of the glymphatic system is thought to lead to build up of toxic proteins including β-amyloid and α-synuclein, and thus may be involved in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) index has been proposed as a marker of glymphatic function.
Aims: To investigate DTI-ALPS in mild cognitive impairment (MCI) and dementia, and determine its relationship with cognitive decline, and biomarkers of neurodegeneration.
Association Between In-Hospital Applications for Long-Term Care Services and Hospital Length of Stay Among Older Adults: Ecological Cross-Sectional Study.
JMIR Form Res
September 2025
Department of Health Economics, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Research Institute, Obu, Japan.
Background: Delayed discharge among older patients presents a major challenge for the efficiency of health service delivery. Prolonged hospitalizations limit bed turnover, increase costs, and reduce the availability of hospital resources. In Japan, older adults must undergo a formal care needs certification process to access public long-term care (LTC) services.
View Article and Find Full Text PDFAssociations Between Sleep Duration and Cognitive Function Among Older Adults: Cross-Sectional Study.
JMIR Hum Factors
September 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Background: Sleep duration plays a crucial role in cognitive health and is closely linked to cognitive decline. However, the relationship between sleep duration and cognitive function in the Chinese population remains poorly understood.
Objective: This study aims to evaluate the association between sleep duration and cognitive function among middle-aged and older adults in China.
Evolution of Motor and Nonmotor Characteristics in an Idiopathic/Isolated REM Sleep Behavior Disorder Cohort.
Neurology
October 2025
Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Background And Objectives: Years before diagnosis of Parkinson disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA), mild prodromal manifestations can be detected. Longitudinal follow-up of people with prodromal synucleinopathy, particularly idiopathic/isolated REM sleep behavior disorder (iRBD), enables in-depth clinical phenotyping of early disease, which could facilitate stratification for clinical trials, provide the definition of appropriate end points, or predict phenoconversion more precisely. The aim of this study was to update and expand on previous studies assessing clinical evolution from iRBD to clinically diagnosed disease, up to 14 years before diagnosis.
View Article and Find Full Text PDF