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Article Abstract
Although transamidation of amides generally requires metals, additives, or harsh conditions, we present here a facile transamidation of -cyano amides with various amines at ambient temperature without any additive. -cyano amides preferred the trans conformation and have a reduced double bond character revealed by crystal analysis. The DFT study indicates that the transamidation reaction proceeds through the direct attack of amine on the amide carbonyl since the LUMO (or LUMO+1) is located at the carbonyl moiety.
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