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http://dx.doi.org/10.1080/10428194.2023.2203286 | DOI Listing |
Cureus
July 2025
Dermatology Department, Allergy Unit, Besançon University Hospital, Besançon, FRA.
Perioperative anaphylaxis is a rare but life-threatening event, with chlorhexidine increasingly recognized as a significant trigger. Though commonly used as an antiseptic due to its broad-spectrum antimicrobial properties, chlorhexidine can lead to sensitization through repeated exposure, resulting in both immediate and delayed hypersensitivity reactions. We report a case of severe perioperative anaphylaxis in a 72-year-old woman following abdominal surgery at the University Hospital of Besançon in May 2024.
View Article and Find Full Text PDFJ Allergy Clin Immunol Pract
August 2025
Platform of molecular analysis for mastocytosis and MCAS, ECNM Reference Center for c-KIT Mutations and other Gene Defects, Sorbonne University, AP-HP, Paris, France; Centre de référence des mastocytoses (CEREMAST), centre constitutif Sorbonne université, AP-HP, hôpital Pitié-Salpêtrière, lab
Mastocytosis represents a group of rare clonal disorders characterized by accumulation of neoplastic mast cells (MC). Disease presentations range from indolent to highly aggressive forms. The discovery of somatic mutations in KIT, particularly KIT p.
View Article and Find Full Text PDFWorld J Clin Cases
July 2025
Department of Pediatrics, Central Michigan University College of Medicine, Mt Pleasant, MI 48859, United States.
Hereditary alpha tryptasemia was first described in 2016 and is the most common (up to 72%) cause of elevated serum basal tryptase (TPS). The clinical presentation of this condition, which is caused by copy number gains in the gene encoding serum α TPS, is variable for each patient. Some patients are asymptomatic, whereas in others, especially those with increased mast cell activation, it has been associated with a higher risk of anaphylaxis.
View Article and Find Full Text PDFInt J Mol Sci
June 2025
Laboratory for Clinical Immunology & Molecular Genetics, University Clinic of Respiratory and Allergic Diseases, 4204 Golnik, Slovenia.
Hereditary α-tryptasemia (HαT)-a genetic trait caused by increased α-tryptase-encoding typtase alpha/beta-1 (TPSAB1) copy number-is associated with adult mastocytosis. The primary objective was to assess the association between α-tryptase and pediatric mastocytosis. We also want to evaluate whether the p.
View Article and Find Full Text PDFFront Allergy
June 2025
Molecular Platform for the Analysis of cKIT Mutations and Other Gene Defects, ECNM Reference Center, Centre National de Référence des Mastocytoses (CEREMAST), Filière MaRIH, Saint-Antoine Hospital, DMU BioGeMH, AP-HP.Sorbonne University, Paris, France.
Monoclonal mast cell disorders (mMCD), including systemic mastocytosis, are characterized by the abnormal accumulation of clonal mast cells, often leading to elevated baseline serum tryptase (bST) levels. Thus, bST evaluation is useful for the diagnosis, classification, and management of patients with mMCD. Hereditary alpha-tryptasemia (HαT) is a relatively frequent genetic trait also characterized by elevated bST levels.
View Article and Find Full Text PDF