α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain.

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Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.

Published: April 2023


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Article Abstract

Changes in brain glucose metabolism occur in many neurological disorders as well as during aging. Most studies on the uptake of glucose in the brain use positron emission tomography, which requires injection of a radioactive tracer. Our study shows that ultra-high-field H-MRS can be used to measure α-D-glucose at 5.22 ppm in vivo, and the α-D-glucose can be used as a radiation-free tracer in the human brain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105689PMC
http://dx.doi.org/10.1038/s41598-023-33161-8DOI Listing

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