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http://dx.doi.org/10.1038/s41375-023-01894-0 | DOI Listing |
Neuropsychopharmacology
September 2025
Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Chronic treatment with fluoxetine, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is known to promote neural plasticity. The role of fluoxetine in plasticity has been particularly tied to parvalbumin-positive interneurons, a key population of GABAergic neurons that regulate inhibitory tone and network stability. While our previous studies have highlighted fluoxetine-induced plasticity in the visual cortex and hippocampus, its cell-type-specific effects in the prefrontal cortex (PFC) remain unclear.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Biology, The University of Saskatchewan, College of Arts and Science, Saskatoon, Canada.
Plasmodesmata are specialized structures in plant cell walls that mediate intercellular communication by regulating the trafficking of molecules between adjacent cells. The actin cytoskeleton plays a pivotal role in controlling plasmodesmatal permeability, but the molecular mechanisms underlying this regulation remain unclear. Here, we report that BRK1, a component of the WAVE/SCAR complex involved in Arp2/3-mediated actin nucleation, localizes to PD and primary pit fields in A.
View Article and Find Full Text PDFmBio
September 2025
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Unlabelled: Methicillin-resistant (MRSA) is a leading cause of endovascular infections, where interactions with endothelial cells play a critical role in pathogenesis. Gp05, a prophage-encoded protein, has previously been implicated in promoting antibiotic persistence by modulating MRSA cellular physiology and evading neutrophil-mediated killing. In this study, we investigated the role of Gp05 in MRSA-endothelial cell interactions, focusing on its impact on bacterial adhesion, invasion, cytotoxicity, and the host inflammatory response.
View Article and Find Full Text PDFCurr Opin Immunol
September 2025
Univ. Grenoble Alpes, CNRS, CEA, UMR5075, IBS, Laboratoire d'Immunologie, CHU Grenoble Alpes, Grenoble, France.
The complement system plays a paradoxical role in systemic lupus erythematosus physiopathology, acting both as a protective mechanism and as a driver of tissue injury, depending on disease stage. Neutrophil extracellular traps (NETs) further exacerbate disease activity by promoting complement activation and autoantigen exposure, forming an amplifying inflammatory loop. Lupus nephritis remains challenging to monitor using conventional complement biomarkers such as CH50, C3, and C4; the utility of anti-C1q, anti-ficolin, and anti-C1s antibodies, along with tissue-based markers such as renal C4d and C5b-9 deposits, as markers of disease activity and prognosis, is discussed.
View Article and Find Full Text PDFISME J
September 2025
Department of Ecology, Environment and Plant Sciences, Stockholm University, Svante Arrhenius väg 20A, SE-106 91 Stockholm, Sweden.
Symbioses between diatoms and the N2-fixing, heterocyst-forming cyanobacterium Richelia spp. are widespread and contribute to primary production. Unique to these symbioses is a variation in the symbiont location: one lives in the host cytoplasm (endobiont) vs.
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