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http://dx.doi.org/10.1183/13993003.02058-2022 | DOI Listing |
Virchows Arch
September 2025
Institute of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany.
Mixed neuroendocrine and non-neuroendocrine neoplasms (MiNEN) represent a heterogeneous group of bidirectionally differentiated epithelial malignancies that are, in most cases, highly aggressive. They are defined by the presence of morphologically distinct, yet clonally related, neuroendocrine and non-neuroendocrine components, each comprising at least 30% of the tumor mass according to current guidelines. Tumors that fall within the differential diagnostic spectrum of MiNEN include amphicrine carcinomas-characterized by the co-expression of neuroendocrine and non-neuroendocrine features within the same tumor cell-as well as conventional carcinomas that lack neuroendocrine morphology but exhibit immunohistochemical expression of neuroendocrine markers.
View Article and Find Full Text PDFBr J Cancer
September 2025
Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
The European Council recommends adopting risk-based screening when relevant. In triaging HPV-positive women, it can be an effective strategy to reduce overtreatment and referral to colposcopy. HPV genotyping and p16/ki67 expression may allow a better risk stratification than cytology.
View Article and Find Full Text PDFInt J Psychophysiol
September 2025
National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan. Electronic address:
The autonomic-based Concealed Information Test (CIT) focuses on differential responses to a crime-relevant item that is significant only for knowledgeable persons. This study examined whether pre-test instructions on question themes defining knowledgeable and unknowledgeable contexts modulate the magnitude of differential responses to the relevant item. The participants (36 men 46 women) were instructed to steal one item from one of two possible locations in a mock theft task.
View Article and Find Full Text PDFEvol Comput
September 2025
Computer Science Department, Tel-Hai College, and The Galilee Research Institute - Migal, Upper Galilee, Israel
Mixed-integer (MI) quadratic models subject to quadratic constraints, known as All- Quadratic MI Programs, constitute a challenging class of NP-complete optimization problems. The particular scenario of unbounded integers defines a subclass that holds the distinction of being even undecidable. This complexity suggests a possible soft-spot for Mathematical Programming (MP) techniques, which otherwise constitute a good choice to treat MI problems.
View Article and Find Full Text PDFJ Craniofac Surg
September 2025
The Private Clinic of Harley Street, London, UK.
The majority of the literature contains outcomes of paediatric otoplasty with multiple surgeons' outcomes. However, to date, a single surgeon's case series numbering over 1000 adult cases in the same center has not been published. Cosmetic ear surgery in adults requires a completely different approach compared with children for the operating surgeon regarding assessment and technique.
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