98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037440 | PMC |
http://dx.doi.org/10.1021/acscentsci.3c00246 | DOI Listing |
Arch Esp Urol
July 2025
Department of Surgery, Suzhou Medical College, Soochow University, 215123 Suzhou, Jiangsu, China.
Background: Lung adenocarcinoma (LUAD) and bladder cancer (BLCA) are two major cancers that have high incidence and mortality worldwide and are particularly exacerbated by smoking, which is a primary risk factor that influences cancer progression through genetic and immune pathways. Temozolomide (TMZ), a chemotherapeutic agent, is often used to treat various cancers, including brain tumours, and is known to induce DNA damage via methylation. This study aims to identify key smoking-related genes, particularly , and explore their mechanisms in LUAD and BLCA, focusing on their prognostic value, role in cancer progression, immune regulation, and response to TMZ.
View Article and Find Full Text PDFGenome Med
June 2025
Department of Life Sciences, Barcelona Supercomputing Center (BSC), C/Jordi Girona 31, Barcelona, 08034, Spain.
Background: Tobacco smoke is the main cause of preventable mortality worldwide. Smoking increases the risk of developing many diseases and has been proposed as an aging accelerator. Yet, the molecular mechanisms driving smoking-related health decline and aging acceleration in most tissues remain unexplored.
View Article and Find Full Text PDFEcotoxicol Environ Saf
July 2025
Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan; Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan; Department of Internal Medicine, En Chu Kong Hospital, Taipei 237, Tai
Purpose: Lead and cadmium have been linked to alterations in DNA methylation (DNAm) and increased mortality. However, the role of smoking-related DNAm in the link between these heavy metals and mortality remains unclear.
Approach And Results: We analyzed data from 2110 participants aged 50 and older from the 1999-2002 National Health and Nutrition Examination Survey (NHANES), linked to mortality data from the National Center for Health Statistics (NCHS) with follow-up through 2019.
BMC Pulm Med
May 2025
Department of Nursing, The Dingli Clinical College of Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou, China.
Cigarette smoking is an important risk factor in lung cancer development. As a class of regulatory RNAs, microRNAs (miRs) participate in various biological processes. In the present study, we searched for the key miRs that mediate cigarette smoke-induced aggressive phenotype in human bronchial epithelial (HBE) cells.
View Article and Find Full Text PDFArch Toxicol
July 2025
Department of Public Health, College of Public Health, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung City, 406040, Taiwan.
While environmental and lifestyle factors contribute to urothelial carcinoma (UC) development, their differential effects on bladder cancer (UB) versus upper tract urothelial carcinoma (UTUC) and the underlying epigenetic mechanisms remain unclear. This study investigated location-specific risk factors and the mediating role of LINE-1 DNA methylation in UC carcinogenesis. A hospital-based case-control study was conducted, comprising 478 UC cases (266 UB, 204 UTUC) and 569 controls.
View Article and Find Full Text PDF