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http://dx.doi.org/10.21470/1678-9741-2023-0961 | DOI Listing |
Brain
September 2025
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, 18016 Granada, Spain.
Primary coenzyme Q (CoQ) deficiency is a mitochondrial disorder with variable clinical presentation and limited response to standard CoQ10 supplementation. Recent studies suggest that 4-hydroxybenzoic acid (4-HBA), a biosynthetic precursor of CoQ, may serve as a substrate enhancement treatment in cases caused by pathogenic variants in COQ2, a gene encoding a key enzyme in CoQ biosynthesis. However, it remains unclear whether 4-HBA is required throughout life to maintain health, whether it offers advantages over CoQ10 treatment, and whether these findings are translatable to humans.
View Article and Find Full Text PDFJ Robot Surg
September 2025
ORSI Academy, Melle, Belgium.
This Letter to the Editor responds to the recent publication by Patel et al. (J Robot Surg. Jul 11;19(1):370, 2025), which outlines a framework and recommendations for telesurgery.
View Article and Find Full Text PDFClin Cardiol
September 2025
Ayub Medical College Abbottabad, Abbottabad, Pakistan.
Rev Cardiovasc Med
August 2025
Department of Cardiology, University Hospitals of Leicester NHS Trust, Glenfield Hospital, LE3 9QP Leicester, UK.
Adult congenital heart disease (ACHD) constitutes a heterogeneous and expanding patient cohort with distinctive diagnostic and management challenges. Conventional detection methods are ineffective at reflecting lesion heterogeneity and the variability in risk profiles. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL) models, has revolutionized the potential for improving diagnosis, risk stratification, and personalized care across the ACHD spectrum.
View Article and Find Full Text PDFThis article considers the calls for police reform and the continuation of police brutality to be twinning modes of policing within Kenya's broader counterterrorism and preventing and countering violent extremism (P/CVE) architecture. Rather than seeing ongoing police brutality as a failure of, or at odds with, calls for police reform, we argue that what appears to be a paradox is actually indicative of a dialectic central to civil counterinsurgency - a dialectic comprising what we call 'coercive compliance' and 'abject coercion'. Based on extensive field research in Kenya, this article centers the institution of the police as an integral mode of P/CVE-as-counterinsurgency to analyze various manifestations of police power, including international compliance vis-a-vis police reform, police brutality, and community engagement.
View Article and Find Full Text PDF