Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Total synthesis of the 2-formylpyrrole alkaloid hemerocallisamine I is presented, both in racemic and enantiopure form. Our synthetic strategy involves (2,4)-4-hydroxyglutamic acid lactone as the key intermediate. Starting from an achiral substrate, the target stereogenic centers were introduced by means of crystallization-induced diastereomer transformation (CIDT) in a highly stereoselective fashion. A Maillard-type condensation was crucial to constructing the desired pyrrolic scaffold.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037412 | PMC |
| http://dx.doi.org/10.3390/molecules28052177 | DOI Listing |
Publication Analysis
Top Keywords
total synthesis
8
24-4-hydroxyglutamic acid
8
acid lactone
8
synthesis hemerocallisamine
4
hemerocallisamine paved
4
paved gram-scale
4
gram-scale synthesis
4
synthesis 24-4-hydroxyglutamic
4
lactone total
4
synthesis 2-formylpyrrole
4