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http://dx.doi.org/10.1093/ced/llad067 | DOI Listing |
J Drugs Dermatol
September 2025
Background: Alopecia universalis (AU) is the most severe form of alopecia areata (AA), characterized by complete scalp and body hair loss. While post-COVID-19 hair loss is often attributed to telogen effluvium (TE), emerging evidence suggests that COVID-19 may also trigger AU through immune dysregulation, particularly via interferon-gamma (IFN-γ)-mediated inflammation. The chronic and relapsing nature of AU raises challenges in long-term disease management, particularly regarding treatment duration and relapse prevention.
View Article and Find Full Text PDFCochrane Database Syst Rev
August 2025
Institute of Clinical Epidemiology, Showa Medical University, Tokyo, Japan.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of scalp cooling for the prevention of hair loss from adjuvant or neoadjuvant chemotherapy in women with early breast cancer.
View Article and Find Full Text PDFClin Genet
July 2025
Departments of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Hypohidrotic ectodermal dysplasias are a genetic condition affecting ectoderm-derived structures such as hair, teeth, nails, and sweat glands, resulting from variations in the EDA, EDAR, EDARADD, and WNT10A genes. This study examined 32 cases from 25 unrelated families from Türkiye, identifying seven novel variants in the EDA, EDAR, and WNT10A genes. The distribution of genetic alterations across the cohort revealed that 44% of the families (11/25) harbored variants in EDA, whereas EDAR and WNT10A variants were identified in 32% (8/25) and 24% (6/25) of families, respectively.
View Article and Find Full Text PDFHum Genomics
July 2025
Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, China.
Background: Congenital hypotrichosis 14 is a nonsyndromic form of alopecia associated with pathogenic variants in the lanosterol synthase (LSS) gene. Recent studies have expanded the spectrum of LSS-related phenotypes, including congenital cataracts, alopecia-intellectual disability syndrome, and palmoplantar keratoderma. Currently, investigations into this disease are still limited, and its treatment remains elusive.
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