Access to Azetidines via Gold Mediated Energy Transfer Photocatalysis.

Org Lett

Department of Chemistry and Centre for Sustainable Chemistry, Ghent University, Campus Sterre, Building S-3, Krijgslaan 281, 9000 Ghent, Belgium.

Published: March 2023


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Article Abstract

The area of energy transfer photocatalysis to generate four-membered rings is experiencing an unprecedented level of activity. Here, we report an operationally simple method toward azetidines from 2-isoxasoline-3-carboxylates and alkenes, using [Au(cbz)(NHC)] complexes as photocatalysts. The procedure enables the reaction for a wide range of substrates. Mechanistic studies confirm the energy transfer pathway. This contribution adds to the earlier reported use of these gold catalysts as a potentially versatile tool in energy transfer chemistry and catalysis.

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http://dx.doi.org/10.1021/acs.orglett.3c00136DOI Listing

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