Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ajh.26879 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A deep learning approach for automatic recognition of abnormalities in the cytoplasm of neutrophils.
Comput Biol Med
August 2024
Hospital Clínic of Barcelona-IDIBAPS, Biochemistry and Molecular Genetics Department, CORE Laboratory, Biomedical Diagnostic, Barcelona, Spain. Electronic address:
Background And Objectives: This study aims to develop and evaluate NeuNN, a system based on convolutional neural networks (CNN) and generative adversarial networks (GAN) for the automatic identification of normal neutrophils and those containing several types of inclusions or showing hypogranulation.
Methods: From peripheral blood smears, a set of 5605 digital images was obtained with neutrophils belonging to seven categories: Normal neutrophils (NEU), Hypogranulated (HYP) or containing cryoglobulins (CRY), Döhle bodies (DB), Howell-Jolly body-like inclusions (HJBLI), Green-blue inclusions of death (GBI) and phagocytosed bacteria (BAC). The dataset utilized in this study has been made publicly available.
Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity.
Vaccines (Basel)
February 2024
Immunology Division, The Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.
Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications of hyposplenism in CD or the optimal pneumococcal vaccination strategy. In this study, the immune effects of hyposplenism in CD, and the accuracy of screening approaches and protective responses induced by two different pneumococcal vaccines were examined.
View Article and Find Full Text PDFRelevance of Howell-Jolly body counts for measuring spleen function in sickle cell disease.
Am J Hematol
May 2023
Centre de Référence MCGRE, Service d'Hématologie-Immunologie, AP-HP, Hôpital Robert Debré, Paris, France.
Spleen Organoid Units Generate Functional Human and Mouse Tissue-Engineered Spleen in a Murine Model.
Tissue Eng Part A
April 2020
Division of Pediatric Surgery and Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Splenectomy is common after trauma or hematologic disease, and alters immune protection against pathogens, which may lead to fulminant infection with high mortality. Yet the spleen has demonstrable regenerative capacity and cells might be recovered and reimplanted at the time of injury or excision to avoid these risks. Tissue-engineered spleen (TESp) was generated from mice (mTESp) or human donor spleen (hTESp) through implantation of spleen organoid units (spleen OU), in NOD/SCID mice with concurrent splenectomy, on a biodegradable scaffold.
View Article and Find Full Text PDF