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Correctional workers form a high-priority group for tuberculosis control measures because of their high exposure and risk. This cross-sectional study conducted in April and May 2022 included 71 criminal police officers from the State Penitentiary of Francisco Beltrão-PR, Brazil. Their sociodemographic and laboratory data were collected. Latent tuberculosis infection (LTBI) was assessed using a QuantiFERON-TB Gold Plus in-tube test kit. Binary logistic regression was applied to calculate the odds ratios (ORs) and 95% confidence intervals (CI) of the LTBI predictors. The prevalence of LTBI was 22.6% (95% CI, 12.8-32.2%). Factors associated with LTBI were age > 43 years (OR, 0.18; 95% CI, 0.04-0.70; p < 0.014) and the use of medications (OR, 5.13; 95% CI, 1.40-18.87; p < 0.014). The prevalence was close to that estimated worldwide for LTBI in correctional workers, reinforcing the need for occupational health control measures consisting of regular screening and treatment of positive cases of latent infection among correctional workers to reduce the risk of illness and spread of infection in the penitentiary system and community.
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http://dx.doi.org/10.1007/s10900-023-01201-z | DOI Listing |
Alveolar macrophages (AMs) are the first immune cells to encounter Mycobacterium tuberculosis (Mtb) in the lungs, but they frequently fail to eliminate this causative agent of tuberculosis (TB), allowing Mtb to persist or replicate. Interstitial macrophages (IMs) are recruited to restrict Mtb growth and limit immune evasion. While IMs have been implicated in the control of acute Mtb infection, their role during latent tuberculosis infection (LTBI) has not yet been explored.
View Article and Find Full Text PDFCoronary artery disease (CAD), tuberculosis (TB), and HIV represent major global health burdens. Individuals affected by one or more of these conditions often exhibit chronic inflammation and immune dysregulation, with monocytes playing a central role in these processes. Monocyte subsets are known to expand in individuals with HIV, TB, or CAD.
View Article and Find Full Text PDFIJU Case Rep
September 2025
Department of Urology Toyama University Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama Japan.
Introduction: The association between the risk of latent tuberculosis infection (LTBI) reactivation and immune checkpoint inhibitor (ICI) administration has been reported.
Case Presentation: A man in his seventies underwent robot-assisted laparoscopic radical cystectomy with ileal conduit diversion for muscle-invasive bladder cancer. Three years postoperatively, CT revealed metastases to the para-aortic lymph nodes and rectum.
J Microbiol Immunol Infect
September 2025
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Background: Interferon-gamma release assays (IGRAs) measure immune responses to pathogen-specific antigens such as tuberculosis. However, the assay hinges on a functional immune system. Whether IGRAs can be used to identify heart transplant candidates with impaired immunity and worse prognosis is not known.
View Article and Find Full Text PDFAm J Health Promot
September 2025
Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, CDC, Atlanta, GA, USA.
PurposeRisk perception for tuberculosis (TB) and previous receipt of a TB test and/or vaccine were assessed to inform TB prevention efforts.DesignCross-sectional.SettingThe 2020, 2021, and 2022 survey data.
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