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http://dx.doi.org/10.1021/acsnano.3c00500 | DOI Listing |
PLoS One
November 2022
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America.
The three-dimensional structure of the synthetic lung Surfactant Protein B Peptide Super Mini-B was determined using an integrative experimental approach, including mass spectrometry and isotope enhanced Fourier-transform infrared (FTIR) spectroscopy. Mass spectral analysis of the peptide, oxidized by solvent assisted region-specific disulfide formation, confirmed that the correct folding and disulfide pairing could be facilitated using two different oxidative structure-promoting solvent systems. Residue specific analysis by isotope enhanced FTIR indicated that the N-terminal and C-terminal domains have well defined α-helical amino acid sequences.
View Article and Find Full Text PDFACS Omega
October 2021
Department of Chemistry, University of the Free State, Nelson Mandela Drive, P.O. Box 339, Bloemfontein 9300, South Africa.
[This corrects the article DOI: 10.1021/acsomega.1c01130.
View Article and Find Full Text PDFJ Phys Chem A
September 2021
Ufa Institute of Chemistry UFRC RAS, 71 Prospect Oktyabrya, 450054 Ufa, Russia.
The mechanisms of enolization and reactions of nucleophilic addition to carbonyl compounds were analyzed by density functional theory (DFT) (PBE1PBE) and (DLPNO-CCSD(T)) level of theory using the interaction of water and hydrogen peroxide with acetone and 1,1,1-trifluoroacetone (TFA) as the reference reactions. The transition states of the studied reactions were localized within the integrated approach that includes both the dielectric continuum theory (polarizable continuum model (PCM)) and the cyclic or two-cluster explicit solvation models. The considered models provide proton transfer in the enolization, hydration, and peroxidation reactions by the Grotthuss mechanism.
View Article and Find Full Text PDFBiomacromolecules
July 2021
Chemistry Department, University of Basel, BPR 1096, Mattenstrasse 24a, 4058 Basel, Switzerland.
Artificial membranes, as materials with biomimetic properties, can be applied in various fields, such as drug screening or bio-sensing. The solvent-assisted method (SA) represents a straightforward method to prepare lipid solid-supported membranes. It overcomes the main limitations of established membrane preparation methods, such as Langmuir-Blodgett (LB) or vesicle fusion.
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