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Background: 'Making Every Contact Count' (MECC) is a public health strategy supporting public-facing workers to use opportunities during routine contacts to enable health behaviour change. A mental health hospital in the North East of England is currently implementing a programme to embed MECC across the hospital supporting weight management ('A Weight Off Your Mind'). Bespoke MECC training has been developed to improve staff confidence in discussing physical activity, healthy eating, and related behaviour change with service users. This article describes the protocol for a pragmatic formative process evaluation to inform the implementation plan for MECC and facilitate successful implementation of the bespoke MECC training at scale.
Methods/design: An 18-month, mixed method pragmatic formative process evaluation, including qualitative research, surveys, document review and stakeholder engagement. This project is conducted within a mental health inpatient setting in the North East of England. Programme documents will be reviewed, mapped against MECC national guidelines, Behaviour Change Techniques (BCTs) and intervention functions within the Behaviour Change Wheel. A cross-sectional survey ( = 365) and qualitative semi-structured interviews ( = 30) will be conducted with healthcare practitioners delivering MECC to assess capability, opportunity and motivation. Data collection and fidelity procedures will be examined, including design, training and delivery dimensions of fidelity. Interviews with service users ( = 20) will also be conducted.
Discussion: Anticipated outcomes include developing recommendations to overcome barriers to delivery of and access to MECC, including whether to either support the use of the existing MECC protocol or tailor the MECC training programme. The findings are anticipated to improve fidelity of MECC training within mental health inpatient settings as well as provide evidence for MECC training at a national level. We also expect findings to influence strategic plans, policy, and practice specific to MECC and inform best practice in implementing wider brief intervention programmes.
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http://dx.doi.org/10.1080/21642850.2023.2174698 | DOI Listing |
Lancet
September 2025
The Lancet, London, UK.
Microorganisms
August 2025
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China.
Methicillin-resistant (MRSA), characterized by high-level β-lactam resistance and increasing multi-drug resistance, poses a severe and growing global threat to human health and public safety. This review examines MRSA's complex resistance mechanisms, including /-mediated expression of low-affinity PBP2a, regulatory roles of auxiliary genes like and , enzymatic inactivation by β-lactamases and modifying enzymes, efflux pump activity, and biofilm formation. We also systematically review novel therapeutic strategies, such as combination therapies, phage-derived biofilm disruptors, membrane-targeting silver nanoparticles, cell-penetrating antimicrobial peptides, colonization-competitive probiotics, and antibiotic-synergizing phytochemicals.
View Article and Find Full Text PDFJ Immunother Cancer
July 2025
University of Washington, Seattle, Washington, USA
Background: Napsin A is normally expressed in human lung pneumocytes and is a highly expressed cancer antigen in lung adenocarcinoma. We examined whether T cells specific for Napsin A may play a role in immune checkpoint inhibitor (ICI)-mediated responses. We used bulk T-cell receptor (TCR) repertoire data to assess whether the presence of Napsin A-specific clonotypes in the peripheral blood was associated with improved clinical responses to ICI.
View Article and Find Full Text PDFEur J Clin Microbiol Infect Dis
July 2025
Leibniz Institute of Photonic Technology (Leibniz-IPHT), Leibniz Center for Photonics in Infection Research (LPI), Jena, 07745, Germany.
Background: Staphylococcus aureus is a common opportunistic pathogen. Methicillin-resistant strains, MRSA, carry SCCmec elements that include beta-lactam resistance genes mecA/mecC. One globally common lineage, Clonal Complex (CC) 15 failed to evolve MRSA until, in 2016, CC15-MRSA were described from Saudi Arabia that carried a SCCmec V element also comprising the fusidic acid resistance gene, fusC.
View Article and Find Full Text PDFBMC Health Serv Res
June 2025
Department for Health, University of Bath, Bath, BA2 7AY, England, UK.
Aim: To a) evaluate the impact of Making Every Contact Count Healthy Conversation Skills (MECC HCS) training on the confidence and competence of physiotherapists in supporting patient behaviour change, and b) evaluate perceived acceptability, barriers and facilitators to implementing MECC HCS, following training.
Methods: A before and after evaluation design was employed. MECC HCS training took place in October and December 2021.