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Article Abstract
We analyzed our challenging experience with a randomized controlled trial of misoprostol for prevention of recurrent C. difficile. Despite careful prescreening and thoughtful protocol modifications to facilitate enrollment, we closed the study early after enrolling just 7 participants over 3 years. We share lessons learned, noting the importance of feasibility studies, inclusion of biomarker outcomes, and dissemination of such findings to inform future research design and implementation successes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793995 | PMC |
| http://dx.doi.org/10.1016/j.anaerobe.2023.102699 | DOI Listing |
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