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Pediatric chronic osteomyelitis is a rare, debilitating condition lacking management guidelines. In a national survey of 162 pediatric infectious disease physicians through the Emerging Infections Network, tremendous variability in diagnostic approaches and management was noted, highlighting a need for a prospective study to better define the spectrum of pathogens and disease.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146934 | PMC |
http://dx.doi.org/10.1093/jpids/piad007 | DOI Listing |
Mater Today Bio
October 2025
Department of Orthopedic Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
Combining disinfection and bone regeneration in a one-step treatment is of significant clinical importance for chronic osteomyelitis, yet it remains a considerable challenge. To address this, we developed a dual stimulus-responsive decellularized extracellular matrix (dECM) cryogel (GC-dECM@CPN). The cryogel is composed of methacrylate gelatin (GelMA), carboxymethyl chitosan (CMCS), dECM, and temperature-sensitive phase-transition copper peroxide nanoparticles (CPNs).
View Article and Find Full Text PDFAvian Pathol
September 2025
North of England Zoological Society (Chester Zoo), Chester, UK.
Avian pseudotuberculosis infection usually presents as well-demarcated visceral necrotic foci, typically affecting the gastrointestinal tract, liver and spleen. This case series describes an atypical presentation of (Yptb) characterized by severe chronic myositis, arthritis and osteomyelitis in five village weavers (), and acute osteomyelitis and myositis associated with septicaemia in an oriental magpie robin () from a zoological collection. Clinical signs of the weavers included lethargy, poor flying ability and focally extensive periarticular and muscular swelling, whereas the magpie robin was found dead without premonitory signs.
View Article and Find Full Text PDFJ Surg Res
September 2025
Nationwide Children's Hospital, Abigail Wexner Research Institute, Columbus, Ohio; Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio; Pediatric Comprehensive Wound Program, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: Jenny.Barker
Introduction: Chronic wounds affect approximately 10.5 million individuals annually in the United States. Although recent studies have highlighted a surge in chronic wound cases among younger populations, the collective burden of pediatric chronic wounds remains understudied.
View Article and Find Full Text PDFCureus
August 2025
Orthopaedics, Mahatma Gandhi Medical College and Research Institute, Pondicherry, IND.
Tuberculous osteomyelitis of the proximal tibia is an extremely rare condition in pediatric patients, often presenting as chronic pain, swelling, and nonspecific symptoms that mimic pyogenic osteomyelitis or bone tumors. We report the case of a three-year-old boy who presented with localized swelling and pain in the right proximal tibia for the past 1.5 months.
View Article and Find Full Text PDFStomatologiia (Mosk)
September 2025
Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Objective: The aim of the study is differential diagnosis of primary chronic osteomyelitis (PCO) and fibrous dysplasia (FD) of the mandible.
Material And Methods: A retrospective comparative study of the case histories of 36 patients with PCO (average age 8.9 years) and 12 patients with FD (average age 8.