Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A well-documented side effect of cannabis and Δ9-tetrahydrocannabinol (THC) acute administration is deficits in cognition and attention. Cannabidiol (CBD), a nonintoxicating constituent of cannabis, may modulate THC's impairing effects. A goal of this study was to determine the effects of THC and CBD, alone and in combination, on performance in the rodent Psychomotor Vigilance Test (rPVT), a translational paradigm used to quantify sustained attention. Outcome measures in the rPVT include motor speed, premature responding, and lapses in attention. Sprague Dawley rats were trained to perform the rPVT to the acquisition criteria and then received oral doses (mg/kg) of THC (1-17.6), CBD (1-100), and combinations of THC + CBD in sesame oil prior to rPVT sessions, administered in a within-subject randomized design. Blood was collected from rats receiving selected doses of THC alone or THC + CBD for analysis of THC and its metabolites. THC alone produced significant decreases in accuracy and increases in lapses in attention at higher doses (10 mg/kg; s < .05). The coadministration of CBD (10 mg/kg) with THC (3 or 10 mg/kg) caused greater impairments to sustained attention compared with administration of THC alone (s < .05). The rPVT is a translational platform sensitive to detect impairments in attention associated with THC and other cannabis constituents. Further work is necessary to determine the mechanism of THC and CBD interactions on impairments in sustained attention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938257 | PMC |
| http://dx.doi.org/10.1037/pha0000635 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the efficiency of cyclodextrin polymers as sustainable sampling material for catching palytoxin-like compounds in seawater.
Mikrochim Acta
September 2025
Marine and Continental Waters, IRTA, Ctra. Poble Nou km 5.5, 43540, La Ràpita, Spain.
Palytoxin-like compounds, including ovatoxins, are potent emerging toxins responsible for human respiratory poisonings following inhalation of contaminated marine aerosols. Periodic massive proliferations of the ovatoxin-producing organism (Ostreopsis cf. ovata) worldwide, particularly in the Mediterranean, have caused severe toxic outbreaks, drawing the attention of health authorities.
View Article and Find Full Text PDFBio-based cellulose aerogels with liquid absorption and retention capability for sustainable personal hygiene applications.
Int J Biol Macromol
September 2025
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China. Electronic address:
Efficient water-absorbing and water-holding materials have shown notable promise in various applications, including hygiene products, agriculture, and drug delivery systems. Opposed to traditional absorbents prepared using synthetic polymers, bio-based, environmentally friendly efficient absorbents have attracted more attention from both academia and the industry. Herein, the aerogel absorbents from functional sodium carboxymethyl cellulose (CMCNa), citric acid (CA) crosslinker, and cellulose nanofibers (CNF) have been developed via freeze-drying and cross-linking process.
View Article and Find Full Text PDFMethuosis caused by dysregulated macropinocytosis, a promising tumor therapeutic strategy.
Pharmacol Res
September 2025
National Key Laboratory of Immunology & Inflammation, Institute of Immunology, Naval Medical University, Shanghai 200433, China. Electronic address:
Nonapoptotic programmed cell death (PCD) has been recognized as potential alternative target for increasing chemosensitivity and augmenting antitumor efficacy. Among various types of nonapoptotic PCD, methuosis has gotten increasing attention recently, largely due to its unique morphological features and potential implications for apoptosis-resistant tumor therapy with negligible side effects. Methuosis is characterized by cytoplasmic vacuolization initiated by sustained macropinocytosis, concomitantly, the other cytotoxic agents from extracellular fluid can be delivered into cytoplasm of tumor cell via macropinocytosis, which can profoundly strengthen the combined antitumor efficacy.
View Article and Find Full Text PDFEffectiveness of low-carbohydrate diets on type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials in Eastern vs. Western populations.
Diabetes Res Clin Pract
September 2025
Siriraj Population Health and Nutrition Research Group (SPHERE), Research Group and Research Network Division, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Electronic address:
Aims: Low-carbohydrate diets (LCDs) have emerged as a potential dietary intervention for managing glycemic control, but their effectiveness across different cultural contexts remains unclear. To evaluate the efficacy of LCDs in managing type 2 diabetes, with attention to cultural context, and to clarify how variability in carbohydrate definitions affects interpretation.
Methods: We searched PubMed, Embase, and Scopus from inception to 1 August 2024 for randomized controlled trials (RCTs) ≥ 12 weeks in adults with type 2 diabetes.
Intersecting precision fermentation for global cell-based food production innovation: Challenges and opportunities.
Biotechnol Adv
September 2025
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruit and Vegetable Processing, Beijing, China; Key Laboratory of Fruit and Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing, Ch
Precision fermentation represents an innovative cell-based production approach that employs synthetic biology and metabolic engineering tools, revolutionizing global food production by utilizing "microbial cell factories" to produce added-value ingredients. However, its global implementation is hindered by technological and scalability bottlenecks, regulatory fragmentation, regional accessibility and consumer acceptance, and nutritional trade-offs challenges. This review utilizes illustrated case studies and modeling analysis to present a detailed exploration of precision fermentation intersecting with global cell-based food production, discussing actionable research gaps and insights as well as advanced bioengineering practices and analytical techniques, to address these challenges for ongoing academic research, industrial applications and policy initiatives, thus supporting the transition of fermentation-enabled food production toward efficient and sustainable manufacturing.
View Article and Find Full Text PDF