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Sensory differences are included in the DSM-5 criteria of autism for the first time, yet it is unclear how they relate to neural indicators of perception. We studied early brain signatures of perception and examined their relationship to sensory behaviors and autistic traits. Thirteen autistic children and 13 Typically Developing (TD) children matched on age and nonverbal IQ participated in a passive oddball task, during which P1 habituation and P1 and MMN discrimination were evoked by pure tones. Autistic children had less neural habituation than the TD comparison group, and the MMN, but not P1, mapped on to sensory overresponsivity. Findings highlight the significance of temporal and contextual factors in neural information processing as it relates to autistic traits and sensory behaviors.
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http://dx.doi.org/10.1007/s10803-022-05866-8 | DOI Listing |
JAACAP Open
September 2025
Columbia University, New York, New York.
Objective: The serotonin system has long been implicated in autism spectrum disorder. A previous study reported lower whole blood serotonin (WB5-HT) concentrations in the mothers of children with more severe autism. This study attempted to replicate this finding in an independent cohort.
View Article and Find Full Text PDFPhysiol Behav
September 2025
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Cognitive Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
The barrel cortex is a specialized region of the primary somatosensory cortex that processes tactile information from whiskers. This study investigates how tactile stimulation (TS) affects excitatory receptive fields and surrounds suppression in barrel cortex neurons of male and female autistic-like rats, using various whisker displacement protocols. The animals were categorized into control, Valproic acid pre-treated (Val), and Val-TS treatment groups.
View Article and Find Full Text PDFBMJ Open
September 2025
University of Maryland College Park, College Park, Maryland, USA.
Introduction: Identifying anxiety disorders in autistic youth can be challenging due to the unique presentation of anxiety symptoms in autistic youth and the difficulties youth may have reporting on their own anxiety symptoms. These challenges underscore the need for objective and reliable measures. Understanding whether autonomic activity is associated with the presence of anxiety may lead to its use as an objective anxiety assessment tool in individuals who may otherwise struggle to communicate their feelings of anxiety.
View Article and Find Full Text PDFBehav Pharmacol
October 2025
Experimental Pharmacology Laboratory, Neurobehavioral Research Laboratory, Department of Pharmacology.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in social interaction, communication, restricted interests, and repetitive behaviors. Its higher prevalence in males underscores the importance of understanding potential sex-specific differences. Prenatal exposure to valproic acid (VPA) is a widely used preclinical model to induce ASD-like traits in rodents; however, few studies have systematically compared neurobehavioral outcomes in both sexes.
View Article and Find Full Text PDFJ Autism Dev Disord
September 2025
Department of Psychology, Centre for Applied Autism Research, University of Bath, Bath, BA2 7AY, UK.
The Dual Process Theory of Autism proposes that those high in autistic traits, including autistic individuals, have both a reduced propensity for intuition and an enhanced propensity for deliberation. Whilst intuition is rapid and autonomous, many factors impact upon deliberation, and an intolerance of uncertainty may mediate the relationship between autistic traits and propensity for deliberation (but not intuition). Two studies were conducted to explore this hypothesis.
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