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California's Central Valley, one of the most agriculturally productive regions, is also one of the most stressed aquifers in the world due to anthropogenic groundwater over-extraction primarily for irrigation. Groundwater depletion is further exacerbated by climate-driven droughts. Gravity Recovery and Climate Experiment (GRACE) satellite gravimetry has demonstrated the feasibility of quantifying global groundwater storage changes at uniform monthly sampling, though at a coarse resolution and is thus impractical for effective water resources management. Here, we employ the Random Forest machine learning algorithm to establish empirical relationships between GRACE-derived groundwater storage and in situ groundwater level variations over the Central Valley during 2002-2016 and achieved spatial downscaling of GRACE-observed groundwater storage changes from a few hundred km to 5 km. Validations of our modeled groundwater level with in situ groundwater level indicate excellent Nash-Sutcliffe Efficiency coefficients ranging from 0.94 to 0.97. In addition, the secular components of modeled groundwater show good agreements with those of vertical displacements observed by GPS, and CryoSat-2 radar altimetry measurements and is perfectly consistent with findings from previous studies. Our estimated groundwater loss is about 30 km from 2002 to 2016, which also agrees well with previous studies in Central Valley. We find the maximum groundwater storage loss rates of -5.7 ± 1.2 km yr and -9.8 ± 1.7 km yr occurred during the extended drought periods of January 2007-December 2009, and October 2011-September 2015, respectively while Central Valley also experienced groundwater recharges during prolonged flood episodes. The 5-km resolution Central Valley-wide groundwater storage trends reveal that groundwater depletion occurs mostly in southern San Joaquin Valley collocated with severe land subsidence due to aquifer compaction from excessive groundwater over withdrawal.
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http://dx.doi.org/10.1016/j.scitotenv.2022.161138 | DOI Listing |
Clin Ther
September 2025
Department of Architecture, Iowa State University, Ames, Iowa.
Environ Monit Assess
September 2025
Department of Forestry Engineering, Federal University of Lavras (UFLA), Lavras, Minas Gerais State, Brazil.
In general, species on our planet are adapted to phenological patterns of vegetation, which are strongly influenced by various climatic and environmental factors that, when altered, can threaten biodiversity. Recent studies have utilized the spatiotemporal variability of vegetation to understand its dynamics, directly affecting biodiversity. Therefore, this research aimed to generate indices of temporal variability considering vegetation phenology and indices of spatial variability of vegetation to subsequently identify priority areas for biodiversity conservation in the Cerrado and Caatinga regions in Minas Gerais State, Brazil.
View Article and Find Full Text PDFSemin Vasc Surg
September 2025
Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; Center for Surgery and Public Health, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:
The rate of end-stage kidney disease (ESKD) is steadily rising in the United States, and older adults (ie, 65 years and older) represent the fastest-growing segment in need of hemodialysis. This demographic shift presents unique challenges due to age-related comorbidities, frailty, and increased procedural risks. Despite these challenges, there is limited guidance for risk stratification and management of renal replacement therapy in older patients with ESKD.
View Article and Find Full Text PDFOrthop J Sports Med
September 2025
Section for Sportstraumatology M51, Bispebjerg-Frederiksberg Hospital, Part of IOC Research Center Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.
Background: Management of the capsulotomy at termination of hip arthroscopic procedures in the treatment of femoroacetabular impingement syndrome (FAIS) is debated. Clinical outcomes in favor of capsular closure were demonstrated in a retrospective study; nonetheless, this finding could not be confirmed in a recent randomized, controlled trial comparing capsular closure with unrepaired capsulotomy.
Purpose/hypothesis: This randomized, controlled multicenter trial aimed to evaluate the effect of capsular closure on subjective postoperative outcomes and revision rates in patients undergoing hip arthroscopy for FAIS.
Curr Drug Saf
September 2025
Department of Pharmaceutics, Jayawantrao Sawant College of Pharmacy and Research, Savitribai Phule Pune University, Pune, 411028, India.
The drug approval and review process plays a crucial role in the pharmaceutical industry, aiming to ensure that newly marketed drugs are safe, effective, and of high quality. Regulatory authorities overseeing this process, tailored to geographically distinct needs, include the U.S.
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