Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00431-022-04762-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spaced learning versus traditional learning for pharmacists implementing β-lactam therapeutic drug monitoring.
Am J Health Syst Pharm
August 2025
Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
Purpose: No consistent recommendations exist on how best to educate pharmacists to facilitate implementation of new evidence-based practices. This study aimed to determine whether spaced learning was more effective than traditional education when learning a new evidence-based practice (β-lactam therapeutic drug monitoring, or TDM).
Summary: β-lactam TDM was implemented in a phased fashion at Mayo Clinic in Rochester.
From PICU to NICU: Extrapolating Meropenem Exposure From Pediatric to Neonatal Intensive Care Patients.
J Clin Pharmacol
August 2025
Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
We previously developed a population pharmacokinetic (PopPK) model for meropenem in pediatric intensive care unit patients accounting for effect of body size, maturation, and kidney function on clearance. This study aimed to extrapolate meropenem exposure to neonates and young infants using the pediatric PopPK model and to validate the predictions using external data. An independent dataset was obtained from the regulations.
View Article and Find Full Text PDFPopulation Pharmacokinetic Model Evaluation with a Small Real-World Dataset Versus a Large Virtual Dataset: Does Sample Size Affect Decision-Making?
Eur J Drug Metab Pharmacokinet
September 2025
Faculté de pharmacie, Université de Montréal, 2940 chemin de Polytechnique, Montréal, QC, H3T 1J4, Canada.
Background And Objective: In a recent simulation-based study, we found that sample size had minimal influence on the external evaluation of population pharmacokinetic (PK) models. However, the applicability of these findings to clinical data remains unexplored. This study aims to validate our previous simulation-based results using real-world clinical data.
View Article and Find Full Text PDFImpact of Dual Antibiotic Prophylaxis on 90-Day Surgical Site Infection Rates Following Posterior Spinal Fusion for Juvenile Scoliosis: A Single-Center Study of 296 Cases.
Medicina (Kaunas)
June 2025
Orthopaedic Unit, Department of Surgery, Bambino Gesù Children's Hospital, 00165 Rome, Italy.
Surgical site infections (SSIs) significantly impact pediatric spinal deformity surgery. Considering the increased risk of Gram-negative infections in neuromuscular scoliosis (NMS), broader antibiotic coverage could be advantageous. Some studies suggest extending this approach to all scoliosis etiologies to reduce SSI rates.
View Article and Find Full Text PDF