Is an Independent Prognostic Factor that Promotes the Progression of Colon Cancer.

Trigger transposable element-derived 1 () is a human-specific gene, but no studies have been conducted to determine its mechanism of action. Our aim is to ascertain the function and mode of action of in the development of colon cancer. The authors used bioinformatics to analyze the relationship between and the clinical characteristics of colon cancer, as well as its prognosis. A series of cell assays were conducted to assess the function of in the proliferation and migration of colon cancer, and flow cytometry was used to explore its effects on apoptosis and the cell cycle. The authors discovered that the expression of was remarkably elevated in colon cancer. Clinical correlation analysis demonstrated that expression was elevated in the tissues of advanced-stage patients, and it was remarkably elevated in individuals with both lymph node and distant metastasis. Further, the authors found that individuals showing elevated expression levels had a shortened survival time. Univariate and multivariate Cox regression analyses revealed that was an independent prognostic factor. Overexpression of the gene remarkedly enhances the proliferation and metastasis of colon cancer cells and suppresses apoptosis. In addition, the overexpression of can enhance the transition of tumor cells from the G1 toward the S phase. Western blot results suggested that may promote the malignant activity of colon cancer cells via the Wnt/β-catenin signaling pathway, Bcl-2, N-cadherin, BAX, E-cadherin, CDK6, and CyclinD1. may be an independent prognostic factor in the advancement of colon cancer, and therefore function as a therapeutic target.