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We developed and tested a novel template matching approach for signal quality assessment on electrocardiogram (ECG) data. A computational method was developed that uses a sinusoidal approximation to the QRS complex to generate a correlation value at every point of an ECG. The strength of this correlation can be numerically adapted into a 'score' for each segment of an ECG, which can be used to stratify signal quality. The algorithm was tested on lead II ECGs of intensive care unit (ICU) patients admitted to the Mount Sinai Hospital (MSH) from January to July 2020 and on records from the MIT BIH arrhythmia database. The algorithm was found to be 98.9% specific and 99% sensitive on test data from the MSH ICU patients. The routine performs in linear O(n) time and occupies O(1) heap space in runtime. This approach can be used to lower the burden of pre-processing in ECG signal analysis. Given its runtime (O(n)) and memory (O(1)) complexity, there are potential applications for signal quality stratification and arrhythmia detection in wearable devices or smartphones.
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http://dx.doi.org/10.1007/s10877-022-00948-5 | DOI Listing |
Sci Adv
September 2025
School of Electrical and Electronic Engineering, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Brain-computer interfaces (BCIs) enable direct communication between the brain and computers. However, their long-term functionality remains limited due to signal degradation caused by acute insertion trauma, chronic foreign body reaction (FBR), and biofouling at the device-tissue interface. To address these challenges, we introduce a multifunctional surface modification strategy called targeting-specific interaction and blocking nonspecific adhesion (TAB) coating for flexible fiber, achieving a synergistic integration of mechanical compliance and biochemical stability.
View Article and Find Full Text PDFCancer Res
September 2025
The Wistar Institute, Philadelphia, PA, United States.
Parkin is a mitochondria-associated E3 ubiquitin (Ub) ligase that mediates mitophagy and organelle quality control. More recently, Parkin has been implicated in stimulating antitumor immunity and reprogramming the tumor immune microenvironment. Here, we showed that Parkin ubiquitinates the alarmin molecule, high mobility group box-1 (HMGB1) on Lys146 (K146) using predominantly K48 linkages.
View Article and Find Full Text PDFPhys Eng Sci Med
September 2025
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia.
This study introduces a novel optimization framework for cranial three-dimensional rotational angiography (3DRA), combining the development of a brain equivalent in-house phantom with Figure of Merit (FOM) a quantitative evaluation method. The technical contribution involves the development of an in-house phantom constructed using iodine-infused epoxy and lycal resins, validated against clinical Hounsfield Units (HU). A customized head phantom was developed to simulate brain tissue and cranial vasculature for 3DRA optimization.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: Carotid artery stenosis is a major cause of stroke. Non-contrast MR angiography (MRA) using time-spatial labeling inversion pulse (Time-SLIP) may offer potential advantages over 3D time-of-flight (TOF)-MRA for simultaneous visualization of carotid, vertebral, and subclavian arteries, but remains uninvestigated.
Purpose: To determine optimal black blood inversion time (TI) for visualizing the carotid and subclavian arteries using three-dimensional (3D) fast field echo (FFE) Time-SLIP MRA, and to compare its image quality with 3D TOF-MRA.
J Agric Food Chem
September 2025
Department of Food Nutrition and Safety/National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing 211198, China.
This study investigated the effects of a low-frequency polarized electric field (LFPEF) on postharvest disease resistance and storage quality of grapes. LFPEF treatment (3 h/d) significantly reduced weight loss, suppressed lesion expansion, and maintained fruit firmness by reinforcing cell wall integrity and enhancing defense-related enzyme activities. Mechanistic analyses indicated that LFPEF activated Ca signaling, promoted calcium accumulation, and upregulated calcium sensor genes, thereby contributing to membrane stabilization.
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