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This study mainly focuses on pre-processing the HAM10000 and BCN20000 skin lesion datasets to select important features that will drive for proper skin cancer classification. In this work, three feature fusion strategies have been proposed by utilizing three pre-trained Convolutional Neural Network (CNN) models, namely VGG16, EfficientNet B0, and ResNet50 to select the important features based on the weights of the features and are coined as Adaptive Weighted Feature Set (AWFS). Then, two other strategies, Model-based Optimized Weighted Feature Set (MOWFS) and Feature-based Optimized Weighted Feature Set (FOWFS), are proposed by optimally and adaptively choosing the weights using a meta-heuristic artificial jellyfish (AJS) algorithm. The MOWFS-AJS is a model-specific approach whereas the FOWFS-AJS is a feature-specific approach for optimizing the weights chosen for obtaining optimal feature sets. The performances of those three proposed feature selection strategies are evaluated using Decision Tree (DT), Naïve Bayesian (NB), Multi-Layer Perceptron (MLP), and Support Vector Machine (SVM) classifiers and the performance are measured through accuracy, precision, sensitivity, and F1-score. Additionally, the area under the receiver operating characteristics curves (AUC-ROC) is plotted and it is observed that FOWFS-AJS shows the best accuracy performance based on the SVM with 94.05% and 94.90%, respectively, for HAM 10000 and BCN 20000 datasets. Finally, the experimental results are also analyzed using a non-parametric Friedman statistical test and the computational times are recorded; the results show that, out of those three proposed feature selection strategies, the FOWFS-AJS performs very well because its quick converging nature is inculcated with the help of AJS.
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http://dx.doi.org/10.3390/cancers14225716 | DOI Listing |
J Strength Cond Res
September 2025
Institute for Data Analysis and Process Design, ZHAW, Zurich, Switzerland; and.
Achermann, BB, Drewek, A, and Lorenzetti, SR. Acute effect of the bounce squat on ground reaction force at the turning point and barbell kinematics. J Strength Cond Res XX(X): 000-000, 2025-The free-weight back squat is a key exercise for developing lower-body strength, with variations that influence muscle activation and performance.
View Article and Find Full Text PDFJ Biomol NMR
September 2025
Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Biomolecular dynamics in the microsecond-to-millisecond (µs-ms) timescale are linked to various biological functions, such as enzyme catalysis, allosteric regulation, and ligand recognition. In solution state NMR, Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion experiments are commonly used to probe µs-ms timescale motions, providing detailed kinetic, thermodynamic, and mechanistic information at the atomic level. For investigating conformational dynamics in high-molecular-weight biomolecules, methyl groups serve as ideal probes due to their favorable relaxation properties, and C CPMG relaxation dispersion is widely employed for characterizing dynamics in selectively CH-labeled samples.
View Article and Find Full Text PDFClin J Sport Med
September 2025
Western University, London, Ontario, Canada.
Objective: Anterior cruciate ligament reconstruction (ACLR) leads to high rates of knee post-traumatic osteoarthritis (PTOA). Physical activity may mitigate PTOA risk but levels after ACLR have not been extensively studied. We aimed to review self-reported and device-measured physical activity levels in individuals with ACLR and compare them with international guidelines, and with uninjured controls.
View Article and Find Full Text PDFJ Obes
September 2025
School of Natural Sciences, University of Lincoln, Lincoln, UK.
To investigate the genetic determinants of fat distribution across anatomical sites and their implications for health outcomes. We analyzed neck-to-knee MRI data from the UK Biobank ( = 37,589) to measure fat at various locations and used Mendelian randomization to assess effects on 26 obesity-related diseases and 94 biomarkers from FinnGen and other consortia. We identified genetic loci associated with 10 fat depots: abdominal subcutaneous adipose tissue ( = 2 loci), thigh subcutaneous adipose tissue (25), thigh intermuscular adipose tissue (15), visceral adipose tissue (7), liver proton density fat fraction (PDFF) (8), pancreas PDFF (11), paraspinal adipose tissue (9), pelvic bone marrow fat (28), thigh bone marrow fat (27), and vertebrae bone marrow fat (5).
View Article and Find Full Text PDFCureus
August 2025
Department of Internal Medicine, Local Health Unit of Santa Maria, Lisbon, PRT.
Polyarteritis nodosa (PAN) rarely affects both intracranial and mesenteric arteries. Evidence on optimal timing of revascularisation and the role of interleukin-6 blockade remains limited. A 73-year-old man with longstanding ankylosing spondylitis presented with weight loss and elevated inflammatory markers.
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