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http://dx.doi.org/10.1186/s12014-022-09378-6 | DOI Listing |
Blood Rev
August 2025
Department of Medicine, Stellenbosch University, Faculty of Medicine and Health Sciences, Tygerberg Campus, South Africa. Electronic address:
Clinicians need a good understanding of available tools to diagnose iron deficiency (ID). Interpretation of commonly used laboratory tests can be challenging due to the dynamic nature of iron homeostasis and concurrent inflammation, which influence results. The misinterpretation of iron studies, inconsistencies in ID diagnostic guidelines, and low awareness of non-anaemic ID may lead to missed diagnoses and opportunities for treatment.
View Article and Find Full Text PDFNew Phytol
September 2025
Horticulture and Product Physiology, Department of Plant Sciences, Wageningen University & Research, Wageningen, 6708 PB, the Netherlands.
Thermal imaging is a key plant phenotyping and monitoring technique but faces major bottlenecks in accurately and efficiently inferring stomatal conductance (g) from leaf temperature. The conductance index (I) was previously proposed to estimate g from thermography by linking temperature differences between real and artificial leaves (ALs) based on the leaf energy balance. However, I is highly sensitive to environmental fluctuations, hampering interpretation and reducing reproducibility.
View Article and Find Full Text PDFNat Commun
September 2025
Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan.
Since Hans Driesch's pioneering work in 1891, it has been known that animal embryos can develop into complete individuals even when divided. However, the developmental processes and molecular mechanisms enabling this self-organization remain poorly understood. In this study, we revisit Driesch's experiments by examining the development of isolated 2-cell stage blastomeres in the sea urchin, Hemicentrotus pulcherrimus.
View Article and Find Full Text PDFProg Nucl Magn Reson Spectrosc
September 2025
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom; School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile; Institute for Biological and Medical
Cardiovascular magnetic resonance (CMR) imaging is an established non-invasive tool for the assessment of cardiovascular diseases, which are the leading cause of death globally. CMR provides dynamic and static multi-contrast and multi-parametric images, including cine for functional evaluation, contrast-enhanced imaging and parametric mapping for tissue characterization, and MR angiography for the assessment of the aortic, coronary and pulmonary circulation. However, clinical CMR imaging sequences still have some limitations such as the requirement for multiple breath-holds, incomplete spatial coverage, complex planning and acquisition, low scan efficiency and long scan times.
View Article and Find Full Text PDFJ Am Soc Echocardiogr
September 2025
Department of Cardiology, University Hospital of Ghent, Ghent University, Ghent, Belgium.
Background: The shape of the continuous wave Doppler (CWD) envelope in functional tricuspid valve regurgitation (fTR) results from the dynamic interplay between flow, pressure gradient and impedance. Although the v-wave cut-off shape in fTR is a well-recognized feature of severe TR, the complete spectrum of TR CWD shapes across the different fTR severity ranges has not been thoroughly explored, which is the scope of the present study.
Methods: In 245 patients with fTR, TR was graded with transthoracic echocardiography using the corrected proximal isovelocity surface area method and CWD shapes were scored, both qualitatively (using visual scoring into parabolic, triangular or v-wave cut-off categories) and quantitatively using a novel Vmax/Vmean parameter and time-to-peak velocity corrected for TR duration (TTP/TRD).