Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: Cyclodextrins (CDs) play a pivotal role in the controlled release of drugs; however, their ability to gradually release drugs is here interrogated: can cyclodextrins, even those that form strong inclusion complexes, sustain a prolonged release of drugs?
Methods: An original chromatographic approach was developed and accordingly we classified and determined drugs that form the most stable inclusion complexes with cyclodextrins. β-CD and hydroxypropyl-β-CD (HP-β-CD) were coupled to pullulan (Pul) microspheres and packed into a chromatographic column. Then, different drugs or model compounds were eluted, and values of the retention time () were determined. release studies were performed for drugs that form the most stable inclusion complexes.
Results: The drugs with the longest value form the most stable inclusion complexes with Pul/β-CD and Pul/HP-β-CD microspheres. Pul/β-CD microspheres form more stable inclusion complexes than Pul/HP-β-CD microspheres. However, in spite of their high stability, they were not able to gradually release the included drug (15 min release time). The cross-chromatographic experiments confirmed the hypothesis that in aqueous solution, drug/cyclodextrin complexes are continuously associated and dissociated.
Conclusions: If the dissociation of the guest molecule is very rapid, why is it expected that these complexes gradually release the drug?
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/17425247.2022.2147159 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent advancements in artificial intelligence-powered cancer prediction from oral microbiome.
Periodontol 2000
September 2025
Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Oral cancer is a major global health burden, ranking sixth in prevalence, with oral squamous cell carcinoma (OSCC) being the most common type. Importantly, OSCC is often diagnosed at late stages, underscoring the need for innovative methods for early detection. The oral microbiome, an active microbial community within the oral cavity, holds promise as a biomarker for the prediction and progression of cancer.
View Article and Find Full Text PDFCommunication about sexuality for adolescents with cerebral palsy and complex communication needs: A scoping review with framework synthesis.
Dev Med Child Neurol
September 2025
School of Health and Social Development, Faculty of Health, Deakin University, Geelong, Australia.
Aim: To understand communication about sexuality for adolescents with cerebral palsy (CP) and complex communication needs.
Method: We systematically searched primary research on adolescents aged 10 to 24 years with CP and/or complex communication needs. We coded the primary evidence against themes derived from a theoretical framework analysis.
Debate: Social media in children and young people - time for a ban? From polarised debate to precautionary action - a population mental health perspective on social media and youth well-being.
Child Adolesc Ment Health
September 2025
Te Puna Hauora/School of Health, Te Herenga Waka/Victoria University of Wellington, Wellington, New Zealand.
Adolescents spend much of their daily lives online, with social media a central part of their digital environment. While findings are complex, evidence increasingly points to small but relatively consistent harms, particularly for those meeting criteria for problematic use. At the population level, these effects are concerning, given the extraordinary prevalence of exposure to social media, rising rates of problematic use and adolescents' vulnerability to mental ill-health.
View Article and Find Full Text PDFExploring how organizational virtuousness shapes nurses' occupational commitment: the mediating role of just culture.
BMC Nurs
September 2025
Department of Nursing Administration, Faculty of Nursing, Alexandria University, Alexandria, Egypt.
Background: Organizational virtuousness and just culture, which both foster justice, honesty, and trust, have a major impact on positive work environments in the healthcare industry. Strengthening nurses' emotional engagement and vocational commitment requires these components. With an emphasis on the mediating function of just culture, this study attempts to investigate the relationship between organizational virtuousness and nurses' vocational commitment.
View Article and Find Full Text PDFHLA polymorphisms in South Tunisian systemic sclerosis patients: a case-control study.
Clin Rheumatol
September 2025
Histocompatibility Department, Hedi Chaker UH, University of Sfax, Sfax, Tunisia.
Objective: Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease. Genetic factors may play a pivotal role in determining susceptibility to these disorders. HLA associations with SSc, especially HLA class II, were investigated in different populations but not in Tunisia.
View Article and Find Full Text PDF