Experimental design by response surface methodology for efficient cefixime uptake from hospital effluents using anion exchange membrane.

The excessive use of antibiotics and their ultimate routes to the environment have prompted the drug resistance, which is becoming a major ecological issue. In this work, we have evaluated the performance of quaternary ammonium poly (2, 6-dimethyl-1,4-phenylene oxide) and polyvinyl alcohol (QPPO/PVA) based anion exchange membrane against cefixime (a third generation cephalosporin antibiotic) present in hospital effluents. The membrane's surface morphology was studied through scanning electron microscopy. The optimization of experimental parameters through Response Surface Methodology helped to evaluate the inter parameter dependence and predict maximum uptake capacity (q). The speculated value of q (6.72 mg g) obtained through central composite design was close to the experimental value of 7.01 mg g with percent relative error of 4.31%. Further, the evaluation of experimental data using isotherms (Langmuir and Freundlich) and kinetic models (pseudo-first-order and second-order) proposed that the interactions between cefixime and the membrane were physisorptive in nature. The intra-day and inter-day assays exhibited lower %RSD values of 0.4% (n = 5) and 0.3% (n = 5). Furthermore, a percentage recovery of 98.2% (n = 9) and limit of detection 1 × 10 μg mL was observed. The chromatogram of the treated water samples presented only negligible amount of cefixime indicating a great potential of QPPO/PVA membrane for the removal of cefixime from real water samples. The membrane could be regenerated for three consecutive cycles without any prominent loss in efficiency.