Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: To investigate peripheral microvascular abnormalities associated with patients with open-angle glaucoma (OAG).
Design: This was a cross-sectional study.
Participants: Patients with OAG and controls.
Methods: All subjects underwent detailed ophthalmic evaluation, including Humphrey visual field (HVF) tests and swept source OCT. To evaluate peripheral microvascular abnormalities, nailfold capillaroscopy (NFC) and laser Doppler imaging (LDI) were performed. The presence of microhemorrhages, tortuous capillaries, dilated capillaries, avascular areas, and the capillary density, among other characteristics, were recorded using NFC; fingertip blood flow (FBF) was measured using LDI at different time points, before and 1, 10, and 20 minutes after exposure to a cold stimulus. In addition, venous blood samples were collected to measure serum endothelin-1 (ET-1) concentrations as well as serum autoantibodies.
Main Outcome Measures: Presence of microhemorrhages, tortuous capillaries, and dilated capillaries; FBF; ET-1; and autoantibodies.
Results: Sixty-eight subjects (43 patients with OAG and 25 controls) were enrolled in the study. Microhemorrhages were found in the nail bed of 65.1% of the patients with OAG compared with 25.0% of the controls (P = 0.003). There was a significant difference in the mean FBF at the baseline in patients with OAG versus controls (293.6 ± 100.2 vs 388.8 ± 52.0 perfusion units, respectively, P < 0.001), together with a significant decrease in the mean FBF 10 and 20 minutes after cold stimulus in patients with OAG in comparison to controls (P < 0.001 for all comparisons). There was a positive correlation between mean baseline FBF and HVF mean deviation (r = 0.27, P = 0.03) and between mean baseline FBF and average retinal nerve fiber layer thickness (r = 0.44, P = 0.001). Neither the analysis of ET-1 concentrations (P= 0.71) nor the autoantibodies measurements (P > 0.05, for all) showed any difference between the 2 groups.
Conclusions: Significant peripheral microvascular abnormalities were found in patients with OAG compared to controls, suggesting that microvascular changes might play a role in the pathogenesis of the disease. In addition, part of these peripheral microvascular abnormalities seems to be correlated with both functional and structural glaucomatous damage.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ogla.2022.10.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical outcomes of Hydrus Microstent implantation for open-angle glaucoma: Results from a large academic center.
Ophthalmol Glaucoma
September 2025
Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Purpose: To assess the clinical outcomes of Hydrus Microstent implantation with cataract extraction for the treatment of open angle glaucoma (OAG) over a maximum of 4 years.
Design: Retrospective, single-center, single-arm, longitudinal cohort study.
Subjects: 308 patients (464 eyes) with OAG who underwent Hydrus Microstent implantation with cataract extraction between February 2019 and December 2021, followed for a median (interquartile range, IQR) of 2.
Resources of Austrian hospital-based departments of neurology and psychiatry for new amyloid-antibody therapies in early Alzheimer dementia : A survey of the Austrian Alzheimer Society.
Wien Klin Wochenschr
September 2025
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Background: Disease-modifying therapies with amyloid-antibodies will soon be available for patients with early Alzheimer's disease, which necessitates diagnostic and therapeutic resources in hospital and outpatient settings.
Methods: The Austrian Alzheimer Society developed an online questionnaire to survey Austrian hospital-based departments of neurology and psychiatry regarding resources for amyloid-antibody therapies.
Results: Between May and October 2023, 30 out of 41 neurology (73%) and 12 out of 33 psychiatry departments (36%) responded.
Cost-utility analysis of latanoprost unidose cationic emulsion preservative-free versus latanoprost unidose in the treatment of open-angle glaucoma and ocular hypertension patients in Spain.
Expert Rev Pharmacoecon Outcomes Res
September 2025
Santen Pharmaceutical, Madrid, Spain.
Background: This study evaluated the efficiency CE-latanoprost unidose (cationic emulsion of latanoprost) versus latanoprost unidose (non-emulsion formulation) in open-angle glaucoma and ocular hypertension (OAG/OHT) with concomitant ocular surface disease (OSD) patients' treatment in Spain.
Methods: A cost-utility analysis was performed using a Markov model simulating the progression of OAG/OHT. From a Spanish National Health System perspective over a 5-year time horizon, quality-adjusted life years (QALYs) and the total cost of each therapy were estimated (annual discount rate: 3%).
Pelvic floor rehabilitation before radical prostatectomy: a systematic review.
BMC Urol
September 2025
University Hospital Santa Maria of Lleida, Gestió de Serveis Sanitaris, Av. Alcalde Rovira Roure 44, 25198, Lleida, Spain.
Objective: To review the effectiveness of pelvic floor muscle strengthening before radical prostatectomy.
Methodology: A search of publications was conducted in the following databases: PubMed, Scopus, Cochrane and Enfispo for articles published from 2019 to September 2024. A total of 199 articles were reviewed, of which 6 were selected and peer-reviewed using the CASPe questionnaire to assess methodological quality, resulting in the inclusion of 5 studies with a total of 642 participants.
One year clinical outcomes with a novel canaloplasty device in mild to severe open angle glaucoma.
Int J Ophthalmol
September 2025
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Aim: To evaluate the one-year clinical outcomes of a novel canaloplasty device used in combination with cataract extraction (CE) in patients with mild to severe open angle glaucoma (OAG).
Methods: This study reviewed patients diagnosed with mild to severe OAG, who underwent canaloplasty with the STREAMLINE® Surgical System combined with CE. The primary outcome was surgical success, defined as achieving ≥20% intraocular pressure (IOP) reduction and/or a reduction of ≥1 glaucoma medication compared to baseline.