Low-Cost In Vivo Full-Range Optical Coherence Tomography Using a Voice Coil Motor.

In this work, we demonstrated a novel and low-cost full-range optical coherence tomography (FROCT) method. In comparison with the off-pivot approach, which needs precise control of the deflecting distance and should be adjusted for different situations, our proposed method is more flexible without regulating the system itself. Different from the previous systems reported in the literature, which used a high-cost piezo-driven stage to introduce the phase modulation, our system utilizes a cost-effective voice coil motor for retrieving the complex-valued spectral signal. The complex-valued data, with a twofold increase in the accessible depth range, can be calculated using an algorithm based on the Hilbert transform and Dirac delta function. To confirm the effectivity of our method, both simulation and experiments were performed. In particular, for the in vivo experiment, we presented the FROCT result of a fingernail fold, demonstrating the availability of in vivo imaging. Since the key element of our system is a low-cost voice coil motor, which is flexible and more accessible for most of the clinics, we believe that it has great potential to be a clinical modality in the future.