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Background: Lumbar epidural analgesia (EA) is the most commonly used method for reducing labour pain, but its impact on the duration of the second stage of labour and on neonatal and maternal outcomes remains a matter of debate. Our aim was to examine whether EA affected the course and the outcomes of labour among patients divided according to the Robson-10 group classification system. Methods: Patients of Robson’s classes 1, 2a, 3, and 4a were divided into either the EA group or the non-epidural analgesia (NEA) group. A propensity score-matching analysis was performed to balance the intergroup differences. The primary goal was to analyse the duration of the second stage of labour. The secondary goals were to evaluate neonatal and maternal outcomes. Results: In total, 21,808 cases were analysed. The second stage of labour for all groups was prolonged using EA (p < 0.05) without statistically significant differences in neonatal outcomes. EA resulted in a lower rate of episiotomies in nulliparous patients, with a higher rate of operative vaginal deliveries (OVD) (p < 0.05) and Caesarean sections (CS) (p < 0.05) in some classes. Conclusions: EA prolonged the duration of labour without affecting neonatal outcomes and reduced the rate of episiotomies, but also increased the rate of OVDs.
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http://dx.doi.org/10.3390/jcm11206124 | DOI Listing |
Chem Biol Interact
September 2025
Department of Systems Medicine. School of Medicine. University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK.
Humans are exposed to mixtures of chemical pollutants from various environmental sources at all stages of life. Understanding how these compounds are causally linked to population health effects is challenging because of the ethical limitations on studying controlled human exposures and the complexity of the many potential molecular mechanisms involved. We hypothesized that studies using a combination of in vivo murine stress reporter models together with non-targeted global transcriptome analysis will define the toxic mechanisms of complex chemical mixtures in a physiological context.
View Article and Find Full Text PDFFree Radic Biol Med
September 2025
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
Metabolic dysfunction-associated steatotic liver disease (MASLD), a leading cause of chronic liver pathology, lacks effective therapies. This study identifies ferroptosis-a lipid peroxidation-driven, iron-dependent form of cell death-as a central pathogenic mechanism in MASLD. Integrative proteomic and histopathological analyses of human and murine MASLD livers revealed marked ferroptosis activation, characterized by dysregulated iron metabolism (reduced FTH1 and GPX4; elevated ACSL4) and oxidative stress.
View Article and Find Full Text PDFGene
September 2025
Institute of Physiology, Medical School, University of Pécs H-7624 Pécs, Hungary. Electronic address:
In this edition of Gene's "Editor's Corner" we summarize the complex interactions of different molecular mechanisms behind the pathogenesis of neonatal hypoxic-ischemic encephalopathy (HIE). The topic is relevant, as the therapeutic options for HIE are limited, it is important to have as much knowledge as possible about the molecular processes underlying the disease. In the recent issue of Gene (Gene 952, 2025, 149363), Wang et al.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
Epilepsy, a highly individualized neurological disorder, affects millions globally. Electroencephalography (EEG) remains the cornerstone for seizure diagnosis, yet manual interpretation is labor-intensive and often unreliable due to the complexity of multi-channel, high-dimensional data. Traditional machine learning models often struggle with overfitting and fail in fully capturing the highdimensional, temporal dynamics of EEG signals, restricting their clinical utility.
View Article and Find Full Text PDFInt J Gynaecol Obstet
September 2025
Department of Obstetrics and Gynecology, Bnai-Zion Medical Center, Technion - Israel Institute of Technology, Haifa, Israel.
Objective: To compare the mode of delivery and other maternal and neonatal outcomes in patients with one prior cesarean delivery undergoing labor induction with a cervical ripening balloon (CRB) for 6 h versus 12 h.
Methods: This retrospective study compared two protocols for mechanical cervical ripening: CRB placement for 12 h (12-h group, implemented from 2014 to 2017) versus 6 h (6-h group, implemented from 2020 to 2021). The study included patients with one prior low-segment cesarean delivery.