Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Women with congenital heart disease at high risk for sudden cardiac death have been poorly studied thus far.
Objectives: The aim of this study was to assess sex-related differences in patients with tetralogy of Fallot (TOF) and implantable cardioverter-defibrillators (ICDs).
Methods: Data were analyzed from the DAI-T4F (French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator) cohort study, which has prospectively enrolled all patients with TOF with ICDs in France since 2010. Clinical events were centrally adjudicated by a blinded committee.
Results: A total of 165 patients (mean age 42.2 ± 13.3 years) were enrolled from 40 centers, including 49 women (29.7%). Among the 9,692 patients with TOF recorded in the national database, the proportion of women with ICDs was estimated to be 1.1% (95% CI: 0.8%-1.5%) vs 2.2% (95% CI: 1.8%-2.6%) in men (P < 0.001). The clinical profiles of patients at implantation, including the number of risk factors for ventricular arrhythmias, were similar between women and men. During a median follow-up period of 6.8 years (IQR: 2.5-11.4 years), 78 patients (47.3%) received at least 1 appropriate ICD therapy, without significant difference in annual incidences between women (12.1%) and men (9.9%) (HR: 1.22; 95% CI: 0.76-1.97; P = 0.40). The risk for overall ICD-related complications was similar in women and men (HR: 1.33; 95% CI: 0.81-2.19; P = 0.30), with 24 women (49.0%) experiencing at least 1 complication.
Conclusions: Our findings suggest that women with TOF at high risk for sudden cardiac death have similar benefit/risk balance from ICD therapy compared with men. Whether ICD therapy is equally offered to at-risk women vs men warrants further evaluation in TOF as well as in other congenital heart disease populations. (French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator [DAI-T4F]; NCT03837574).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jacep.2022.06.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Large Cerebral Abscess in a Patient of Tetralogy of Fallot.
Ann Afr Med
September 2025
Department of Medicine, KGMU, Lucknow, Uttar Pradesh, India.
Brain abscess is a rare but dangerous suppurative infection. Incidence of congenital heart disease varies from 5% to 18.7%.
View Article and Find Full Text PDFConotruncal Anomalies of the Fetus.
Ultraschall Med
September 2025
Division of Prenatal Medicine, Gynecological Ultrasound and Fetal Surgery, Department of Obstetrics and Gynecology, University Hospital, Cologne, Germany.
Approximately 0.8 % of all children are born with heart defects, with the prenatal incidence naturally being even higher. Among all congenital heart defects (CHD), conotruncal anomalies are the most common critical heart defects - after ventricular and atrial septal defects.
View Article and Find Full Text PDFPersistent Fifth Aortic Arch in a Right-Sided Aortic Arch Associated With Tetralogy of Fallot.
JACC Case Rep
September 2025
The Heart Centre for Children, Sydney Children's Hospitals Network, Sydney, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, Australia. Electronic address:
Persistent fifth aortic arch is a rare congenital cardiac anomaly. We report the imaging findings of a subtype of persistent fifth aortic arch in an infant with tetralogy of Fallot and a right-sided aortic arch.
View Article and Find Full Text PDFCharacterizing the recurrence of atrial arrhythmia following macro-reentrant atrial tachycardia ablation in adult patients with repaired tetralogy of Fallot.
Heart Rhythm O2
August 2025
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Background: The recurrence of arrhythmia following catheter ablation of macro-reentrant atrial tachycardia (MRAT) in repaired tetralogy of Fallot (rTOF) is poorly understood.
Objective: To better describe the incidence, mechanisms, and predictors of recurrent atrial arrhythmia following MRAT ablation in rTOF.
Methods: Patients with rTOF ≥18 years of age who underwent radiofrequency ablation for MRAT (typical/cavotricuspid isthmus-dependent atrial flutter, incisional/scar-mediated MRAT, upper and lower-loop reentry, or left atrial MRAT) at Duke University Hospital from 1996 to 2023 were identified.
A Deep Learning-Based Fully Automated Cardiac MRI Segmentation Approach for Tetralogy of Fallot Patients.
J Magn Reson Imaging
September 2025
Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan.
Background: Automated cardiac MR segmentation enables accurate and reproducible ventricular function assessment in Tetralogy of Fallot (ToF), whereas manual segmentation remains time-consuming and variable.
Purpose: To evaluate the deep learning (DL)-based models for automatic left ventricle (LV), right ventricle (RV), and LV myocardium segmentation in ToF, compared with manual reference standard annotations.
Study Type: Retrospective.