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Background: Meal replacement therapy (MRT) is a structured treatment that is effective for short-term weight reduction in adolescents with severe obesity. However, like other interventions, MRT response is variable.
Objective: The goal of the current study was to characterize the experience of adolescents with severe obesity participating in MRT.
Methods: Seventeen adolescents with severe obesity participated in semi-structured, individual interviews about their experience participating in MRT. The authors used a biopsychosocial model as the theoretical framework and data was analysed using Interpretive Phenomenological Analysis. A biopsychosocial model views an individual's health as a blend of biological characteristics, behavioural factors, and social conditions.
Results: Results showed that adolescents with severe obesity described three biopsychosocial factors that were central to their experience with MRT: (1) scheduling and planning, (2) social support and pressure, and (3) intrapersonal factors. Specifically, adolescents with severe obesity identified that planning ahead, social support, and intrapersonal changes (e.g. self-confidence) can promote engagement in MRT. On the other hand, unplanned schedule changes, social pressures, and different intrapersonal factors (e.g., taste preference) can make engagement challenging.
Conclusions: Adolescents provided information on factors that supported or hindered their engagement in MRT, and themes were consistent with prior literature on health behaviour change. Overall, adolescents would recommend MRT to other teenagers who carry extra weight. Future research can use the rich information provided by adolescents with severe obesity to enhance and individualize treatment options.
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http://dx.doi.org/10.1111/ijpo.12986 | DOI Listing |
Pediatr Blood Cancer
September 2025
Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Background: The suppressor of tumorigenesis 2 (ST2) has emerged as one of the most promising biomarkers for predicting mortality of acute graft-versus-host disease (aGvHD) when measured at the onset of symptoms, but detailed time course studies are needed to understand the potential of ST2 as a risk marker of both aGvHD and chronic graft-versus-host disease (cGvHD), potentially allowing pre-emptive adjustment of immunosuppressive treatment.
Procedure: We measured ST2 levels in 117 children undergoing standard hematopoietic stem cell transplantation (HSCT) before conditioning and at regular intervals post-HSCT.
Results: ST2 levels were significantly increased from Day +7 in patients developing aGvHD of any grade (no GvHD: 23.
BMJ Open Sport Exerc Med
August 2025
School of Physiotherapy, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Objectives: To describe training loads and injury incidences, and explore their relationship in senior schoolboy rugby players in Leinster, Ireland.
Methods: Prospective cohort study conducted during the 2019-2020 season. Methods aligned with consensus statements for rugby injury surveillance research.
BMJ Public Health
August 2025
Department of Public Health, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Background: Comprehensive studies on attitudes towards menstruation and the prevalence of premenstrual syndrome (PMS) and its associated factors among adolescents are limited. Since both attitudes and responses towards PMS are shaped by psychosocial and cultural factors, this study was conducted to assess attitude towards menstruation, prevalence of PMS and coping mechanisms adopted to manage PMS among adolescent girls in Kerala, with a focus on psychosocial experiences rather than the biological aspects of PMS.
Methods: An institution-based cross-sectional study was conducted among 1100 adolescent girls (aged 13-19 years), selected through multistage cluster sampling.
J Educ Health Promot
July 2025
Dental Students' Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Orthodontic malocclusions could affect oral health-related quality of life (OHR-QoL). The aim of this study was to evaluate the impact of overjet, overbite, and anterior crowding on OHR-QoL of adolescents.
Materials And Methods: This cross-sectional study involved 143 adolescents (71 boys and 72 girls) aged 10-15 years seeking orthodontic treatment.
J Inflamm Res
September 2025
Department of Optometry, School of Health and Welfare, Dongshin University, Naju, Korea.
Objective: To evaluate the therapeutic efficacy and inflammatory modulatory effects of combined 0.01% atropine eye drops and orthokeratology (OK) lenses in controlling myopia progression among adolescent patients.
Methods: This retrospective study analyzed clinical data from 90 adolescent patients (90 eyes) with myopia treated from April 2021 to June 2023.