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http://dx.doi.org/10.1016/j.ejca.2022.09.006 | DOI Listing |
bioRxiv
August 2025
Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
The duration of antibody production varies across different infections and vaccines. To define molecular programs that promote durable humoral immunity, we used mice deficient in ZBTB20, a transcription factor that is highly expressed by plasma cells and required to maintain antibody production . However, genetic deletion of in long-lived plasma cells had no impact on the duration of antibody production.
View Article and Find Full Text PDFVaccines (Basel)
August 2025
4th Department of Internal Medicine, Attikon University Hospital, 12462 Athens, Greece.
We aimed to synthesize and critically evaluate human studies on the impact of circadian and sleep factors on influenza vaccine-induced immune responses. A comprehensive literature review was conducted, and of the 1260 studies identified, 13 met the inclusion criteria for evaluating vaccination timing, circadian misalignment, and sleep parameters in relation to influenza vaccine-induced immune responses in human populations. Most studies assessed humoral immune responses, primarily antibody titers.
View Article and Find Full Text PDFVaccines (Basel)
July 2025
Department of Experimental Research, Medical University-Pleven, 5800 Pleven, Bulgaria.
Background: Understanding the duration and quality of immune memory following SARS-CoV-2 infection and vaccination is critical for informing public health strategies and vaccine development. While waning antibody levels have raised concerns about long-term protection, the persistence of memory B cells (MBCs) and T cells plays a vital role in sustaining immunity.
Materials And Methods: We conducted a longitudinal prospective study over 12 months, enrolling 285 participants in total, either after natural infection or vaccination with BNT162b2 or mRNA-1273.
BMJ Paediatr Open
August 2025
Hospital da Criança de Brasília José Alencar, Brasília, Brazil.
Background: The humoral response to SARS-CoV-2 is not fully understood, especially in children. This study provides valuable insights into the durability of adaptive immunity in paediatric patients who were unvaccinated and naturally infected with the prototype strain of SARS-CoV-2, including those who were asymptomatic or had pre-existing chronic and rare disorders. This study aimed to analyse the antibody response to SARS-CoV-2 during infection and over a 1-year follow-up period in patients aged 0-18 years who were admitted to a tertiary paediatric hospital at the onset of the COVID-19 pandemic.
View Article and Find Full Text PDFMicrobiol Spectr
August 2025
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Unlabelled: This study integrated multisource longitudinal data with trajectory modeling to delineate the heterogeneity of humoral immune dynamics induced by inactivated SARS-CoV-2 vaccinations and their clinical implications for subsequent SARS-CoV-2 infection outcomes in 205 individuals from Sichuan Province, China. We found that preexisting infection status served as the dominant stratifier of antibody trajectory divergence across the cohort. Additionally, among individuals without prior infection before the vaccine cohort, we identified five distinct immune response patterns with clinical implications.
View Article and Find Full Text PDF