98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/EJA.0000000000001756 | DOI Listing |
Angew Chem Int Ed Engl
August 2025
Fakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany.
Reliable, broadly applicable cross-coupling conditions that deliver the desired products with minimal optimization are essential in pharmaceutical research, where efficient synthesis accelerates lead discovery and late-stage diversification. Although advances like high-throughput additive screening and commercial catalyst/ligand libraries improve prediction in specific systems, a general strategy for vinyl halide cross-coupling across diverse bond-forming reactions remains elusive. Herein, we report a general and highly predictable method for vinyl halide cross-coupling under photoredox conditions, employing two complementary catalytic systems.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Working Group on CMR, Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Background: Late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance (CMR) is an established metric for risk stratification and therapeutic guidance. However, consensus on the optimal technique for quantifying left ventricular (LV) LGE extent remains lacking. This study aimed to identify the most reliable method for quantifying LGE in chronic myocardial infarction (CMI), hypertrophic cardiomyopathy (HCM), and inflammatory heart disease (IHD).
View Article and Find Full Text PDFColloids Surf B Biointerfaces
August 2025
Department of Urology, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang 315021, PR China. Electronic address:
Accurate differentiation of prostate cancer at various stages provides a reliable basis for clinical decision-making in cancer treatment. However, there is still no effective protocol to enable the rapid and accurate identification of cancer progression. With the aim to improve the diagnostic efficiency of prostate cancer at different stages, we systematically analyzed exosomes derived from prostate cancer at different stages of disease progression by integrating surface-enhanced Raman spectroscopy (SERS) with principal component analysis (PCA) in this work.
View Article and Find Full Text PDFbioRxiv
July 2025
Department of Pediatrics, Division of Critical Care Medicine, University of California San Francisco, San Francisco, CA.
After birth, the alveolar capillary network expands to increase gas exchange surface area and endothelial-derived signals promote alveolarization. Lung capillaries are comprised of two distinct subsets, one with proliferative potential to facilitate growth and repair (Cap1), and the other serving a specialized role in gas exchange (Cap2). However, the molecular mechanisms directing capillary speciation, developmental plasticity, and fate transitions during development and repair are not well understood.
View Article and Find Full Text PDFMicroorganisms
June 2025
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala s/n, Del. Miguel Hidalgo, Ciudad de México 11340, Mexico.
The main aspects of brucellosis have been studied in animal models to better understand the pathogenesis of the disease. Mice are the most common animal model of brucellosis. To verify that the infection has been successfully induced, it is necessary to assess the presence of in experimentally infected mice.
View Article and Find Full Text PDF