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Article Abstract
Objective: is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in India. The present investigation aimed to determine the anti-inflammatory and anti-arthritic activity of ethanolic extract of roots (EECT) in animal models.
Methods: The anti-inflammatory activity of the EECT was evaluated by carrageenan and histamine-induced paw edema.
Results: EECT showed a significant reduction in mean paw edema volume in both carrageenan and histamine-induced inflammation. The efficacy of EECT in rheumatoid arthritis was tested against Freund's complete adjuvant (CFA) induced arthritic model in Wistar rats. The anti-arthritic effect of EECT was determined by systematic scoring of arthritis symptoms and measuring paw edema. A considerable decrease in paw diameter was observed in the EECT (200 and 400 mg/kg) and diclofenac (10 mg/kg) treated groups after day 7. Diclofenac (10 mg/kg) and EECT (400 mg/kg) showed a significant reduction in paw diameter from day 14 compared with CFA control ( < 0.001). The anti-arthritic activity was also confirmed from the altered biochemical, haematological (Hb, RBC and WBC) and anti-oxidant parameters (SOD, MDA, CAT, and GSH). EECT (400 and 200 mg/kg) also showed a marked inhibition of joint destruction.
Conclusion: This study provides a pharmacological rationale for the traditional use of against inflammation and rheumatoid arthritis in India.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476680 | PMC |
| http://dx.doi.org/10.1016/j.chmed.2020.11.004 | DOI Listing |
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