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Article Abstract
In this paper, in the presence of trimethylsilyl iodide, the direct -C-H hydroxyalkylation/methylation of aryl iodines was effectively realized via palladium/norbornene cooperative catalysis when low-cost tetrahydrofuran and 1,2-dimethoxyethane were used as alkyl sources. Heck, Suzuki, and Sonogashira coupling and hydrogenation were all compatible with the reaction as termination steps. In addition, neuromuscular agents and cardiovascular agents were synthesized in one step by this method, showing their potential application value.
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| http://dx.doi.org/10.1021/acs.orglett.2c02425 | DOI Listing |
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