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Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.

Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.

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Cerrado ash reduces volatile emissions from faeces but does not influence the olfactory responses of the dung beetles.

Naturwissenschaften

September 2025

Laboratório de Ecologia E Conservação de Invertebrados, LECIN, Departamento de Ecologia E Conservação, Instituto de Ciências Naturais, Universidade Federal de Lavras, PO Box 3037, CEP 37.203-202, Lavras, MG, Brasil.

Fire is a key natural disturbance influencing physical, chemical, and biological processes in the Cerrado. Ash, a fire byproduct, may significantly influence soil macrofauna through its chemical properties. Dung beetles (Scarabaeinae), critical components of Cerrado soil macrofauna, provide key ecological functions and services.

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Structure Engineering Enabled O-O Radical Coupling in Spinel Oxides for Enhanced Oxygen Evolution Reaction.

J Am Chem Soc

September 2025

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University, Tianjin 300071, China.

Developing cost-effective spinel oxide catalysts with both high oxygen evolution reaction (OER) activity and stability is crucial for advancing sustainable clean energy conversion. However, practical applications are often hindered by the activity limitations inherent in the adsorbate evolution mechanism (AEM) and the stability limitations associated with the lattice oxygen mechanism (LOM). Herein, we demonstrate structural changes induced by phase transformation in CoMn spinel oxides, which yield more active octahedral sites with shortened intersite distance.

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Tibia-Fibula Relative Motion During Gait Cycle by 2D-3D Registration.

J Orthop Res

September 2025

Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, Chaoyang District, China.

Injuries to the distal tibiofibular joint are often associated with ankle fractures, sports-related injuries, or instability, whereas proximal tibiofibular joint injuries are more commonly present with lateral- or posterolateral-compartment lesions of the knee. These conditions may be related to the relative motion between the tibia and fibula; however, precise movement patterns have yet to be fully elucidated. This study analyzes the relative motion of the tibia and fibula in 16 healthy adults (32 bones; 8 males and 8 females) throughout a normal gait cycle.

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The supported catalytically active liquid metal solution (SCALMS) concept is based on catalytically active metals dissolved in a low-melting-point liquid metal matrix. These solid alloy particles, deposited over a high area support, transform into a liquid alloy under reaction conditions. In this work, GaPt SCALMS materials of varying composition are investigated and focus on the change in the alloy composition during preheating, the actual high temperature propane dehydrogenation at 823 K, and after cool-down.

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