Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Repetitive transcranial magnetic stimulation (rTMS) has become an increasingly popular tool to modulate neural excitability and induce neural plasticity in clinical and preclinical models; however, the physiological mechanisms in which it exerts these effects remain largely unknown. To date, studies have primarily focused on characterizing rTMS-induced changes occurring at the synapse, with little attention given to changes in intrinsic membrane properties. However, accumulating evidence suggests that rTMS may induce its effects, in part, via intrinsic plasticity mechanisms, suggesting a new and potentially complementary understanding of how rTMS alters neural excitability and neural plasticity. In this review, we provide an overview of several intrinsic plasticity mechanisms before reviewing the evidence for rTMS-induced intrinsic plasticity. In addition, we discuss a select number of neurological conditions where rTMS-induced intrinsic plasticity has therapeutic potential before speculating on the temporal relationship between rTMS-induced intrinsic and synaptic plasticity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928958 | PMC |
| http://dx.doi.org/10.1177/10738584221118262 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CUX1 restrains latent hematopoietic stem cell plasticity by suppressing stem cell-intrinsic inflammatory pathways.
Blood
September 2025
The University of Chicago, Chicago, Illinois, United States.
Long-term maintenance of somatic stem cells relies on precise regulation of self-renewal and differentiation. Understanding the molecular framework for these homeostatic processes is essential for improved cellular therapies and treatment of myeloid neoplasms. CUX1 is a widely expressed, dosage-sensitive transcription factor crucial in development and frequently deleted in myeloid neoplasia in the context of -7/(del7q).
View Article and Find Full Text PDFSpatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypes.
Front Immunol
September 2025
Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Intrinsic genetic alterations and dynamic transcriptional changes contribute to the heterogeneity of solid tumors. Lung adenocarcinoma (LUAD) is characterized by its significant histological, cellular and molecular heterogeneity. The present study aimed to study the spatial transcriptomics of primary LUAD with initial hopes to decipher molecular characteristics of subtype transitions in LUAD progression, offering new insights for novel therapeutic strategies.
View Article and Find Full Text PDFFactors affecting locomotor plasticity in Rhodnius prolixus.
J Insect Physiol
September 2025
Instituto René Rachou, Avenida Augusto de Lima, 1715, CEP 30190-009, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
Triatomines are vectors of Trypanosoma cruzi, the causative agent of Chagas disease. Their locomotor activity is influenced by endogenous and exogenous factors, but whether individual behavioral profiles persist across developmental stages remains unclear. This study evaluated non-oriented locomotor activity in Rhodnius prolixus under varying nutritional states (short-fasting, long-fasting, fed), developmental stages (5th instar nymphs and adults), sex (males and females), and light phase (photophase vs.
View Article and Find Full Text PDFAging-related adaptations of metabotropic glutamate receptors within the CA3 region of the rat hippocampus.
Neurobiol Aging
September 2025
Departamento de Farmacobiología. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 14330, Mexico. Electronic address:
The physiological decline associated with aging is often accompanied by a progressive deterioration in cognitive processing abilities driven by a series of cellular dysfunctions that remain poorly understood. In the hippocampus, a critical area for learning and memory, aging affects the functional expression of ionotropic and metabotropic receptors, including the metabotropic glutamate receptors (mGluRs). mGluRs play a critical role in multiple cellular functions, including modulation of ion channels and intrinsic excitability, synaptic transmission, and induction of synaptic plasticity, processes considered part of the cellular substrates for learning and memory.
View Article and Find Full Text PDFArctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance.
J Fish Biol
September 2025
Department of Biological Sciences, University of New Brunswick - Saint John, Saint John, New Brunswick, Canada.
Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to which they seasonally adjust cardiac thermal performance and adrenergic control. We assessed the intrinsic and maximum heart rate (f and f) of anaesthetised fish through cholinergic blockade and either adrenergic blockade (f) or stimulation (f) during acute warming.
View Article and Find Full Text PDF