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Altered microRNA expression correlates with reduced TLR2/4-dependent periodontal inflammation and bone resorption induced by polymicrobial infection.
Microbiol Spectr
August 2025
Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Unlabelled: Periodontitis (PD) is a polymicrobial dysbiotic immuno-inflammatory disease. Toll-like receptors (TLRs) are present on gingival epithelial cells and recognize pathogen-associated molecular patterns on pathogenic bacteria, inducing the secretion of proinflammatory cytokines and initiating innate and adaptive antigen-specific immune responses to eradicate the invading microbes. Since PD is a chronic inflammatory disease, TLR2/TLR4 play a vital role in disease pathogenesis and in maintaining the periodontium during health.
View Article and Find Full Text PDFAdult intracranial bacterial abscesses in Ireland (2010-2021) associated with a low mortality. Luck of the Irish?
Br J Neurosurg
July 2025
Department of Clinical Microbiology, Cork University Hospital, Cork, Ireland.
Objectives: To describe the epidemiology, microbiology and clinical outcomes of adult patients (aged ≥16 years) diagnosed with bacterial intracranial abscesses in the Republic of Ireland.
Methods: A 12-year retrospective analysis from 2010 to 2021 was conducted in the Republic of Ireland's two neurosurgical centres. Radiological, microbiological, and medical records of adult patients with confirmed intracranial abscesses were analysed.
Advanced Age in Mice Exacerbates Sepsis-Induced Inflammation, Vascular Permeability, and Multi-Organ Dysfunction.
Shock
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Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sepsis is a life-threatening syndrome marked by a dysregulated immune response to an infection and significant endothelial vascular permeability, often leading to multi-organ failure. Elderly patients are particularly vulnerable to sepsis, with higher morbidity and mortality rates. We hypothesized that advanced age exacerbates sepsis-induced inflammation and endothelial vascular permeability, resulting in a delayed recovery, persistent inflammation, and sustained organ injury.
View Article and Find Full Text PDFPhysiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes.
Nat Immunol
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Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Recent studies have highlighted the presence of memory T cells in human brains, some of which are specific for peripheral infections. To address their potential origins, we used two models of polymicrobial exposure to 'normalize' the immune systems of specific pathogen-free mice and queried the impact on brain T cell biology. Here, we show that cohousing and sequential infection induce marked enhancement of memory T cells in the brain tissue of mice.
View Article and Find Full Text PDFPorphyromonas gingivalis: Multiple Tools of an Inflammatory Damage.
Mol Oral Microbiol
October 2025
Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Periodontitis (periodontal disease [PD]) is a complex inflammatory disease caused by a polymicrobial infection that facilitates the destruction of the connective tissue and bone that support the teeth. PD is highly correlated with cardiovascular disease, low birth weight, preterm osteoporosis, Alzheimer's disease, and rheumatoid arthritis. Porphyromonas gingivalis, a main causative agent of PD, is a non-motile, asaccharolytic, Gram-negative bacterium identified in subgingival, supragingival, and tongue sites in patients.
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