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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395168 | PMC |
| http://dx.doi.org/10.1016/S1473-3099(22)00547-3 | DOI Listing |
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Right ventricular uncoupling in acute heart failure with preserved or mildly reduced ejection fraction: a simple parameter to predict long-term mortality.
Arch Peru Cardiol Cir Cardiovasc
June 2025
Heart failure, pulmonary hypertension and heart transplant department. Instituto Cardiovascular de Buenos Aires. Buenos Aires, Argentina. Heart failure, pulmonary hypertension and heart transplant department Instituto Cardiovascular de Buenos Aires Buenos Aires Argentina.
Introduction: Risk prediction in acute heart failure (AHF) has led to the development of multiple prognostic models. Emerging data highlight the prognostic significance of right ventricular (RV) to pulmonary artery (PA) uncoupling, which has been linked to adverse outcomes. Among patients with heart failure with preserved ejection fraction (HFpEF) and mildly reduced ejection fraction (HFmrEF), a highly heterogeneous group, the prognostic relevance of RV-PA uncoupling in forecasting long-term mortality is still not well defined.
View Article and Find Full Text PDFOxylipins are Associated With Poor Right Ventricular to Pulmonary Artery Coupling and Adverse Outcomes in Heart Failure With Preserved Ejection Fraction.
Am J Cardiol
July 2025
Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio. Electronic address:
Right ventricular (RV) coupling to pulmonary artery (PA) pressure is a key parameter in heart failure with preserved ejection fraction (HFpEF). Oxylipins, a class of fatty acid signaling molecules that regulate inflammation, may be associated with RV-PA uncoupling. We sought to determine the association of RV-PA uncoupling with clinical outcomes in HFpEF and to discover oxylipins associated with RV-PA uncoupling.
View Article and Find Full Text PDFPrognostic value of right ventricle-pulmonary artery uncoupling in elderly patients hospitalized for heart failure with preserved ejection fraction.
Curr Probl Cardiol
September 2025
Cardiology Department, Hospital Italiano de Buenos Aires, Argentina.
Background: The TAPSE/PASP ratio reflects right ventricle-pulmonary artery (RV-PA) coupling and has prognostic value in patients with heart failure, regardless of left ventricular ejection fraction (LVEF). The objective of this study was to assess the prognostic impact of the TAPSE/PASP ratio in elderly patients hospitalized for acute heart failure with preserved ejection fraction (HFpEF).
Methods: Prospective, observational, and single-center cohort study included patients aged ≥75 years, hospitalized for HFpEF (LVEF >50 %) from September 2019 to December 2023.
Exercise Doppler Echocardiography of the Right Heart and Pulmonary Circulation in Patients With Cardiovascular Risk Factors: Observations From the RIGHT Heart International NETwork (RIGHT-NET).
Chest
June 2025
Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy; Interdepartmental Center for Gender Medicine Research "GENESIS", Germany. Electronic address:
Background: The precise impact of cardiovascular risk factors (CVRFs) on the right ventricle-pulmonary circulation unit remains unclear.
Research Question: Are there any differences regarding resting and exercise right ventricular function in patients with CVRFs but without overt cardiovascular disease when compared with healthy control patients?
Study Design And Methods: We extracted from the Right Heart International Network international registry the data of 362 patients with at least 1 CVRF but no overt cardiovascular disease, and 375 healthy control patients. All patients and control patients had undergone resting and exercise echocardiographic evaluations on a semirecumbent cycle ergometer.
Right ventricular to pulmonary artery uncoupling is an early predictor of poor outcome in wild-type transthyretin amyloid cardiomyopathy.
Int J Cardiovasc Imaging
June 2025
Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Non-invasive right ventricular to pulmonary artery (RV-PA) uncoupling assessment has prognostic value in patients with heart failure (HF). Little is known about its application in patients with wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM). This single-centre retrospective study included consecutive patients with wtATTR-CM diagnosis undergoing 2D echocardiogram.
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