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Pituitary apoplexy is a rare but potentially fatal endocrinological emergency which can be difficult to diagnose as presenting symptoms vary significantly. Optimal management requires early diagnosis and collaboration between ophthalmology, endocrinology and neurosurgical services. We present a case of pituitary apoplexy in a 52-year-old Caucasian female who was referred by her optometrist to Palmerston North Hospital Eye Clinic with a three-week history of sudden onset moderate bifrontal headaches, two weeks of non-specific peripheral visual changes and dense bitemporal inferior quadrantanopia on formal visual field testing. Ocular motility and slit lamp examination were unremarkable and retinal nerve fibre layer (RNFL) was relatively preserved on optical coherence tomography (OCT). MRI demonstrated a haemorrhagic pituitary macroadenoma elevating and compressing the optic chiasm without cavernous extension. Blood tests revealed mild hypothyroidism, hypocortisolism, hypogonadotropism and hyperprolactinaemia. The patient was commenced on hydrocortisone and levothyroxine replacement and proceeded for urgent transsphenoidal tumour resection at Wellington Regional Hospital. Histology revealed a non-functioning macroadenoma. The patient was asymptomatic and visual field tests had normalised three weeks post-operatively. Six weeks post-operatively, thyroid function and cortisol levels were normal and replacement therapies were ceased.
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http://dx.doi.org/10.26635/6965.5721 | DOI Listing |
Radiol Case Rep
November 2025
Department of Mother and Child Radiology-Chu Hassan Ii, Sidi Mohammed Ben Abdellah University, Hrazem Hospital Center, P.O. Box 1835 Atlas, Fez, Morocco.
Pituitary apoplexy is an uncommon but potentially fatal syndrome of the pituitary gland, caused by ischemia, hemorrhage, or necrosis that can occur with or without a pre-existing pituitary neuroendocrine tumor (PitNET), as reported during pregnancy and in lymphocytic hypophysitis. We present in this paper a case of an 11-year-old girl with pituitary apoplexy. Our patient experienced sudden deterioration in her left eye vision and a headache.
View Article and Find Full Text PDFIntern Med
August 2025
Division of Nephrology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Hypopituitarism can cause various psychiatric disorders. We herein report the case of a 60-year-old female with hypopituitarism who presented with severe hyponatremia, impaired consciousness, and delusional disorder. Brain imaging revealed a pituitary macrotumor with hemorrhaging, and the laboratory findings suggested panhypopituitarism.
View Article and Find Full Text PDFAnn Ital Chir
August 2025
Department of Neurosurgery, The First Affiliated Hospital of Bengbu Medical University, 233004 Bengbu, Anhui, China.
Aim: To explore the differences in clinical features between patients with pituitary apoplexy and those without, analyze the risk factors for pituitary apoplexy, evaluate the incidence of postoperative complications between patients with pituitary apoplexy and those without, and investigate the risk factors for postoperative complications to provide clinical guidance for diagnosis and treatment.
Methods: In this retrospective analysis, clinical data of 108 pituitary tumor patients admitted between January 2020 and July 2024 were collected. The patients were divided into two groups: the pituitary apoplexy group ( = 50) and the pituitary non-apoplexy group ( = 58).
AACE Endocrinol Diabetes
April 2025
Department of Endocrinology, Lebanese American University Medical Center-Rizk Hospital (LAUMCRH), Beirut, Lebanon.
Background/objective: Pituitary apoplexy (PA) is a rare and life-threatening emergency that remains prone to misdiagnosis, especially in pregnancy. Few cases of gestational PA have been reported in the literature.
Case Report: This study reports a case of a 26-year-old woman presenting at 35 weeks of gestation with PA.
Clin Med (Lond)
July 2025
Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Academic Department of Endocrinology, Beaumont Hospital, RCSI Smurfit Building, Dublin, Ireland. Electronic address:
The management of pituitary disorders in pregnancy presents a unique challenge for maternal medicine specialists and endocrinologists. Advances in assisted reproductive technologies (ART) mean that women with hypopituitarism are increasingly able to conceive. The pituitary undergoes significant physiological changes during pregnancy.
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