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http://dx.doi.org/10.1016/j.ejim.2022.08.011 | DOI Listing |
J Chromatogr A
August 2025
Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland. Electronic address:
∆-tetrahydrocannabinol (∆-THC) plays a major role in diving under the influence of drugs investigations and workplace drug testing. Additionally, cannabidiol (CBD), as well as semi-synthetic cannabinoids, like hexahydrocannabinol (HHC) and ∆-tetrahydrocannabinol (∆-THC), are increasingly found on regulated and unregulated drug markets. A straightforward bioanalytical method was developed, covering 14 analytes, including ∆-THC, CBD, ∆-THC, and their respective metabolites, as well as HHC and a subset of minor phytocannabinoids.
View Article and Find Full Text PDFBiomedicines
August 2025
Department of Internal Medicine, Asthma and Allergy, Medical University, 90-153 Łódź, Poland.
Treatment compliant with the Global Initiative for Asthma (GINA) can promote more effective disease control. Single-inhaler triple therapy (SITT) is one method that is used to optimize therapy in this context, but TRIPLE therapy is still employed by physicians to a limited extent. This study aimed to describe the factors influencing challenges in optimizing asthma therapy.
View Article and Find Full Text PDFBackground: Chronic obstructive pulmonary disease (COPD) is a progressive illness characterized by persistent respiratory symptoms and restricted airflow, often owing to smoking and prolonged exposure to environmental irritants. COPD affects the pulmonary vasculature, lung parenchyma, and airways, leading to structural abnormalities such as emphysema. This study compares the safety and effectiveness of budesonide/glycopyrrolate/formoterol fumarate (BGF) metered-dose inhaler (MDI) with glycopyrrolate/formoterol fumarate (GFF) MDI in patients with moderate to severe COPD, focusing on adverse events and forced expiratory volume in 1 second (FEV1).
View Article and Find Full Text PDFEur J Histochem
June 2025
Section of Histology and Embryology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia; Regenerative Medicine Research Center, Fondazione IRCCS Policlinico San Matteo, Pavia.
The statement "Plastics define the way we live today" summarizes the findings of the Plastic Europe 2020 final document (https://plasticseurope.org/knowledge-hub/plastics-the-facts-2020/). Sadly, this also means that the plastic waste generated over the next decade is likely to become unmanageable.
View Article and Find Full Text PDFEClinicalMedicine
September 2025
Respiratory and Immunology, Clinical Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Background: Pressurised metered dose inhalers (pMDIs) contain a hydrofluorocarbon propellant, such as hydrofluoroalkane-134a (HFA-134a), which is known to have global warming potential (GWP). Transitioning pMDIs to propellants with lower GWP will reduce the environmental impact of pMDIs. This study assessed the safety of a near-zero GWP propellant, hydrofluoroolefin-1234ze (HFO-1234ze), compared with HFA-134a when used in the delivery of budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) in participants with chronic obstructive pulmonary disease (COPD).
View Article and Find Full Text PDF