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Two randomized controlled trials demonstrated no clinical benefit of hydroxychloroquine (HCQ) for either postexposure prophylaxis or early treatment of SARS-CoV-2 infection. Using data from these studies, we calculated the time-weighted average change from baseline SARS-CoV-2 viral load and demonstrated that HCQ did not affect viral clearance.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538473 | PMC |
http://dx.doi.org/10.1002/jmv.28054 | DOI Listing |
Reg Anesth Pain Med
September 2025
Center for Outcomes Research and Department of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.
Background: Skeletal muscle relaxants are often included in multimodal analgesic regimens following spine surgery, but their actual effectiveness remains unclear due to limited and inconsistent evidence. We aimed to evaluate the effectiveness of intravenous methocarbamol in reducing acute postoperative pain and opioid consumption after elective spine surgery.
Methods: This emulated target trial used electronic health record data from patients undergoing elective spine surgery (posterior spinal fusion, anterior cervical discectomy and fusion, laminectomy/laminotomy) between January 1, 2020 and December 31, 2023.
Ecotoxicol Environ Saf
September 2025
State Key Laboratory of Advanced Environmental Technology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
The lack of centralized sewage treatment in rural areas has led to severe underestimation of pharmaceutical pollution, posing significant risks to aquatic ecosystems and human health. While wastewater-based epidemiology (WBE) is widely used to estimate pharmaceutical consumption in urban settings, its dependence on sewage infrastructure leads to monitoring deficiencies in rural watersheds with direct wastewater discharges into rivers. Here, we pioneer the application of organic-diffusive gradients in thin-films (o-DGT) passive sampling to conduct WBE in a representative rural area of Hunan Province, China, which lacks sewage treatment facilities.
View Article and Find Full Text PDFJ Clin Monit Comput
September 2025
Department of Anesthesiology, University of Groningen, University Medical Center Groningen, PO Box 30.001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Purpose: Pediatric patients undergoing cardiac surgery are at risk of developing postoperative acute kidney injury (AKI). We hypothesized that a reduction in intraoperative renal (SrO) or cerebral (ScO) tissue oxygen saturation is associated with postoperative AKI.
Methods: We conducted a prospective observational study including fifty pediatric patients with non-cyanotic heart disease undergoing elective surgical repair with cardiopulmonary bypass.
Ren Fail
December 2025
Division of Cardiology, Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Aims: To validate the effectiveness of intensive glycemic control in preventing acute kidney injury (AKI) among patients with coronary artery disease (CAD) and prediabetes.
Methods: This investigation employed data from the Prospective Registry of the Current Status of Care for Patients with CAD database. Glycemic control was evaluated using the time-weighted average glucose (TWAG) and the glucose coefficient of variation (CV) for each participant.
J Hazard Mater
August 2025
Department of Intelligent Precision Healthcare Convergence, Institute for Cross-disciplinary Studies (ICS), Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea; Department of Biomedical Engineering, ICS, SKKU, Suwon, Gyeonggi 16419, Republic of Korea. Electronic address: chunpar
This study evaluated volatile organic compound (VOC) emissions, microplastic fiber shedding, and in vitro cytotoxicity of 29 commercial sanitary pads, and modeled potential user exposures. We analyzed ten VOCs released from pads using gas chromatography-mass spectrometry, quantified microplastics shed, and performed cytotoxicity assays with cultured mammalian cells exposed to pad extracts and direct contact. Toluene was the only VOC detected (<0.
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