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http://dx.doi.org/10.1515/cclm-2022-0542 | DOI Listing |
Arch Pharm (Weinheim)
September 2025
College of Chemistry, Pingyuan Laboratory (Zhengzhou University), Zhengzhou University, Zhengzhou, China.
The SARS-CoV-2 pandemic has spurred global efforts to develop therapeutic approaches. The main protease (Mpro) of SARS-CoV-2 is crucial for viral replication and a key target for therapeutic development. In this study, 22 thiosemicarbazone derivatives were synthesized.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Cardiology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.
The relationship between dietary habits, including the consumption of eggs, dairy products, and sugar, and the development of disease is well-established. However, further investigation is required to elucidate the precise associations between these dietary habits and cardiovascular disease (CVD). The objective of this study was to analyze existing genome-wide association studies in order to identify causal relationships between dietary habits and CVD.
View Article and Find Full Text PDFChem Biodivers
September 2025
KU Institute for Advanced Studies, Kasetsart University, Bangkok, Thailand.
Erythrodontium julaceum, Marchantia polymorpha, and Plagiochila bantamensis are widely distributed bryophytes in Vietnam. However, comprehensive chemical and biological data on their composition remain limited. Bio-guided isolation based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) M inhibition was applied to these species, resulting in the identification of 23 metabolites.
View Article and Find Full Text PDFJ Infect Dev Ctries
August 2025
Department of Medical Microbiology, Faculty of Medicine, Ege University, Izmir 35100, Turkey.
Introduction: The aim of this study was to compare the performance of different clinical specimens-nasopharyngeal (NP) swabs collected by healthcare professionals (HCP-NP), self-collected nasal swabs (Sc-N), and saliva samples (S)-in diagnostic tests for investigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and influenza A/B RNA.
Methodology: These clinical samples were collected from 404 symptomatic cases and tested with the SARS-CoV-2 and influenza A/B RNA tests on the cobas 6800 System of Roche Molecular Systems (Roche Molecular Systems, Pleasanton, USA). The SARS-CoV-2 or influenza virus infection status was determined for all patients based on the predefined criteria and corresponding algorithms.
Microbiol Spectr
September 2025
Laboratoy of Virology, Microbiology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Millions of reverse transcription-polymerase chain reaction (RT-PCR) tests have been performed worldwide during the SARS-CoV-2 pandemic, using various protocols. This study evaluates the duration of SARS-CoV-2 RNA detectability by RT-PCR at body temperature and analyzes changes in cycle threshold (Ct) values over time. Positive nasopharyngeal swabs for SARS-CoV-2 RT-PCR ( = 120) with different Ct values were collected from Hospital Universitario 12 de Octubre (Madrid, Spain, 2020).
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