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Children exposed to adverse childhood experiences (ACEs) and pervasive interpersonal traumas may go on to develop PTSD and, in most cases, will further undergo a significant shift in their developmental trajectory. This paper examines contemporary research on Developmental Trauma (DT), which is inextricably linked to disruptions in social cognition, physiological and behavioral regulation, and parent-child attachments. Developmental trauma associated with early experiences of abuse or neglect leads to multi-faceted and longstanding consequences and underscores critical periods of development, complex stress-mediated adaptations, and multilevel, trans-theoretical influences in the diagnostic formulation and treatment of traumatized children, adolescents, and adults. Psychological and medical correlates of Developmental Trauma Disorder are considered, and directions for future research are discussed.
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http://dx.doi.org/10.3389/fpsyt.2022.800687 | DOI Listing |
Cochrane Database Syst Rev
September 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Background: Radiotherapy is the mainstay of treatment for head and neck cancer (HNC) but may induce various side effects on surrounding normal tissues. To reach an optimal balance between tumour control and toxicity prevention, normal tissue complication probability (NTCP) models have been reported to predict the risk of radiation-induced side effects in patients with HNC. However, the quality of study design, conduct, and analysis (i.
View Article and Find Full Text PDFNat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFExp Dermatol
September 2025
Department of Surgery, Chang Bing Show Chwan Memorial Hospital, Lukang, Taiwan.
Radiation dermatitis is a common side effect of radiotherapy, affecting up to 95% of cancer patients receiving radiation therapy and often leading to skin damage, inflammation, and ulceration. The pathogenesis of radiation dermatitis involves complex mechanisms, such as the production of reactive oxygen species (ROS) and sustained inflammatory responses. Current treatments, including topical steroids, moisturisers, and non-steroidal anti-inflammatory drugs (NSAIDs), often provide limited efficacy, primarily addressing symptoms rather than the underlying pathophysiological processes.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Orthopedics and Traumatology, Brazilian Association for the Welfare of the Handicapped Children (AACD), São Paulo, SP, Brazil.
Hip dysplasia in cerebral palsy (CP) is a common and severe problem, especially among nonambulatory patients. A likely cause is muscular imbalance and developmental bone changes leading to a progressive extrusion of the femoral head from the acetabulum. The ideal surgical treatment aims to reduce the dislocated hip to improve pain, positioning, and function.
View Article and Find Full Text PDFPerspect Behav Sci
September 2025
Department of Psychological Studies in Education, Temple University, 1301 Cecil B. Moore Avenue, Philadelphia, PA 19122 USA.
This commentary critically appraises attacks on applied behavior analysis (ABA) from outside and-increasingly-within the field. Commonly repeated attacks are that ABA is coercive and suppresses individual identity, aligns with the medical model, causes trauma, and, in more extreme cases, constitutes abuse. We illustrate how these claims are based on unfounded criticism and longstanding myths about ABA and stand in direct contrast to the empirical foundations of behavior analysis.
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